Intracellular functions of galectins

Fu-Tong Liu, Ronald J. Patterson, John L. Wang

Research output: Contribution to journalArticle

468 Citations (Scopus)

Abstract

Many galectin family members are detected primarily intracellularly in most of the systems studied, although certain members can be found both inside and outside of cells. Specific functions that are consistent with their intracellular localization have now been documented for some of the galectins. Galectin-1 and -3 have been identified as redundant pre-mRNA splicing factors. Galectin-3, -7, and -12 have been shown to regulate cell growth and apoptosis, being either anti-apoptotic or pro-apoptotic. Galectin-3 and -12 have been shown to regulate the cell cycle. In some cases, the mechanisms by which galectins exert their functions have been partially delineated in relation to known intracellular pathways associated with these processes. In addition, a number of intracellular proteins involved in these processes have been identified as the interacting ligands of certain galectins. This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)263-273
Number of pages11
JournalBiochimica et Biophysica Acta - General Subjects
Volume1572
Issue number2-3
DOIs
StatePublished - Sep 19 2002

Fingerprint

Galectins
Galectin 3
Galectin 1
RNA Precursors
Cell growth
Cell Cycle
Cells
Apoptosis
Ligands
Growth
Proteins

Keywords

  • Apoptosis
  • Cell cycle
  • Cell growth
  • Galectin
  • Galectin-interacting protein
  • RNA splicing

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Intracellular functions of galectins. / Liu, Fu-Tong; Patterson, Ronald J.; Wang, John L.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1572, No. 2-3, 19.09.2002, p. 263-273.

Research output: Contribution to journalArticle

Liu, Fu-Tong ; Patterson, Ronald J. ; Wang, John L. / Intracellular functions of galectins. In: Biochimica et Biophysica Acta - General Subjects. 2002 ; Vol. 1572, No. 2-3. pp. 263-273.
@article{688281407513457fb7c754000c41e420,
title = "Intracellular functions of galectins",
abstract = "Many galectin family members are detected primarily intracellularly in most of the systems studied, although certain members can be found both inside and outside of cells. Specific functions that are consistent with their intracellular localization have now been documented for some of the galectins. Galectin-1 and -3 have been identified as redundant pre-mRNA splicing factors. Galectin-3, -7, and -12 have been shown to regulate cell growth and apoptosis, being either anti-apoptotic or pro-apoptotic. Galectin-3 and -12 have been shown to regulate the cell cycle. In some cases, the mechanisms by which galectins exert their functions have been partially delineated in relation to known intracellular pathways associated with these processes. In addition, a number of intracellular proteins involved in these processes have been identified as the interacting ligands of certain galectins. This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms.",
keywords = "Apoptosis, Cell cycle, Cell growth, Galectin, Galectin-interacting protein, RNA splicing",
author = "Fu-Tong Liu and Patterson, {Ronald J.} and Wang, {John L.}",
year = "2002",
month = "9",
day = "19",
doi = "10.1016/S0304-4165(02)00313-6",
language = "English (US)",
volume = "1572",
pages = "263--273",
journal = "Biochimica et Biophysica Acta - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Intracellular functions of galectins

AU - Liu, Fu-Tong

AU - Patterson, Ronald J.

AU - Wang, John L.

PY - 2002/9/19

Y1 - 2002/9/19

N2 - Many galectin family members are detected primarily intracellularly in most of the systems studied, although certain members can be found both inside and outside of cells. Specific functions that are consistent with their intracellular localization have now been documented for some of the galectins. Galectin-1 and -3 have been identified as redundant pre-mRNA splicing factors. Galectin-3, -7, and -12 have been shown to regulate cell growth and apoptosis, being either anti-apoptotic or pro-apoptotic. Galectin-3 and -12 have been shown to regulate the cell cycle. In some cases, the mechanisms by which galectins exert their functions have been partially delineated in relation to known intracellular pathways associated with these processes. In addition, a number of intracellular proteins involved in these processes have been identified as the interacting ligands of certain galectins. This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms.

AB - Many galectin family members are detected primarily intracellularly in most of the systems studied, although certain members can be found both inside and outside of cells. Specific functions that are consistent with their intracellular localization have now been documented for some of the galectins. Galectin-1 and -3 have been identified as redundant pre-mRNA splicing factors. Galectin-3, -7, and -12 have been shown to regulate cell growth and apoptosis, being either anti-apoptotic or pro-apoptotic. Galectin-3 and -12 have been shown to regulate the cell cycle. In some cases, the mechanisms by which galectins exert their functions have been partially delineated in relation to known intracellular pathways associated with these processes. In addition, a number of intracellular proteins involved in these processes have been identified as the interacting ligands of certain galectins. This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms.

KW - Apoptosis

KW - Cell cycle

KW - Cell growth

KW - Galectin

KW - Galectin-interacting protein

KW - RNA splicing

UR - http://www.scopus.com/inward/record.url?scp=0037136410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037136410&partnerID=8YFLogxK

U2 - 10.1016/S0304-4165(02)00313-6

DO - 10.1016/S0304-4165(02)00313-6

M3 - Article

C2 - 12223274

AN - SCOPUS:0037136410

VL - 1572

SP - 263

EP - 273

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

SN - 0304-4165

IS - 2-3

ER -