Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden

PREDICT-HD Investigators of the Huntington Study Group

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV across 15 neuropsychological tasks and within-task IIV using a self-paced timing task were compared as a single measure of processing speed (Symbol Digit Modalities Test [SDMT]) in 693 gene-expanded and 191 nongene-expanded participants from the PREDICT-HD study. After adjusting for depressive symptoms and motor functioning, individuals estimated to be closest to HD diagnosis displayed higher levels of across- and within-task variability when compared to controls and those prodromal HD participants far from disease onset (FICV(3,877) = 11.25; pPacedTiming(3,877) = 22.89; p

Original languageEnglish (US)
Pages (from-to)8-21
Number of pages14
JournalJournal of the International Neuropsychological Society
Volume21
Issue number1
DOIs
StatePublished - Nov 12 2014

Keywords

  • Adult
  • Attention
  • Cognition disorders/diagnosis
  • Cognition disorders/genetics
  • Executive function
  • Huntington disease
  • Intra-individual variability
  • Neuropsychological tests
  • Prodromal symptoms

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language

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