Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm

E. S. Nussbaum, R. C. Heros, E. E. Solien, M. T. Madison, L. A. Sebring, Richard E Latchaw, R. G. Dacey, B. K A Weir, W. R. Selman, R. A. Solomon, M. R. Mayberg, A. L. Day

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

WE TESTED THE effect of intra-aortic balloon counterpulsation (IABC) on cerebral blood flow (CBF) in a canine model of cerebral vasospasm. Cerebral vasospasm was induced in ten adult mongrel dogs using a 'two-hemorrhage' model. CBF was then measured using radiolabeled microspheres, before and after activation of an intra-aortic balloon pump. Physiologic parameters including pCO2 and cardiac filling pressures were maintained constant during the experiment. Cardiac output was monitored in each animal. CBF increased with IABC in all ten animals. The mean CBF was 78.5 milliliters per 100 grams per minute (ml/100g/min) before versus 93.3ml/100g/min after IABC (P=0.0001). Increases in CBF were associated in most, but not all, cases with increases in cardiac output. This study supports the ability of IABC to raise CBF in the setting of cerebral vasospasm. IABC may represent an important clinical option in cases of refractory vasospasm following aneurysmal subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)879-886
Number of pages8
JournalNeurosurgery
Volume36
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Counterpulsation
Intracranial Vasospasm
Subarachnoid Hemorrhage
Canidae
Cardiac Output
Microspheres
Dogs
Hemorrhage
Pressure

Keywords

  • Cerebral blood flow
  • counterpulsation
  • intra-aortic balloon pump
  • stroke
  • subarachnoid hemorrhage
  • vasospasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Nussbaum, E. S., Heros, R. C., Solien, E. E., Madison, M. T., Sebring, L. A., Latchaw, R. E., ... Day, A. L. (1995). Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm. Neurosurgery, 36(4), 879-886.

Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm. / Nussbaum, E. S.; Heros, R. C.; Solien, E. E.; Madison, M. T.; Sebring, L. A.; Latchaw, Richard E; Dacey, R. G.; Weir, B. K A; Selman, W. R.; Solomon, R. A.; Mayberg, M. R.; Day, A. L.

In: Neurosurgery, Vol. 36, No. 4, 1995, p. 879-886.

Research output: Contribution to journalArticle

Nussbaum, ES, Heros, RC, Solien, EE, Madison, MT, Sebring, LA, Latchaw, RE, Dacey, RG, Weir, BKA, Selman, WR, Solomon, RA, Mayberg, MR & Day, AL 1995, 'Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm', Neurosurgery, vol. 36, no. 4, pp. 879-886.
Nussbaum, E. S. ; Heros, R. C. ; Solien, E. E. ; Madison, M. T. ; Sebring, L. A. ; Latchaw, Richard E ; Dacey, R. G. ; Weir, B. K A ; Selman, W. R. ; Solomon, R. A. ; Mayberg, M. R. ; Day, A. L. / Intra-aortic balloon counterpulsation augments cerebral blood flow in a canine model of subarachnoid hemorrhage-induced cerebral vasospasm. In: Neurosurgery. 1995 ; Vol. 36, No. 4. pp. 879-886.
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AU - Weir, B. K A

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