Intestinal lymphoma of granular lymphocytes in a fisher (martes pennanti) and a eurasian otter (lutra lutra)

Susan L. Bartlett, Denise Imai, John G. Trupkiewicz, Michael M. Garner, Seigo Ogasawara, Tracy Stokol, Matti Kiupel, Noha Abou-Madi, George V. Kollias

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intestinal lymphoma of granular lymphocytes was diagnosed in a 6-year-old fisher (Martes pennanti) and a geriatric Eurasian otter (Lutra lutra). Clinical signs included lethargy and inappetance in both animals and vomiting and occasional diarrhea in the fisher. The diagnosis in both cases was made using cytology of fresh tissue, histology of fixed tissues, and immunohistochemistry. Granules were seen most clearly on cytologic examination of direct impressions from fresh tissue. Because granules were absent in most histologic sections, cytology of fresh tissue was essential for the diagnosis. Immunohistochemistry determined that the neoplastic cells had positive membranous immunoreactivity to CD3 and were negative for CD79a, which was consistent with alimentary T-cell lymphoma. The disease course in both animals was presumed to be aggressive, with rapid progression of clinical signs, high mitotic index and effacement of local intestinal architecture in both cases, and metastatic disease in the fisher. To the authors' knowledge, this is the first report of lymphoma of granular lymphocytes in a fisher and a Eurasian otter.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalJournal of Zoo and Wildlife Medicine
Volume41
Issue number2
DOIs
StatePublished - Jun 21 2010

Fingerprint

Otters
Mustelidae
Lutra lutra
Martes
lymphoma
Lymphoma
lymphocytes
Lymphocytes
cell biology
immunohistochemistry
Cell Biology
granules
Immunohistochemistry
Lethargy
Mitotic Index
T-Cell Lymphoma
vomiting
disease course
Geriatrics
histology

Keywords

  • Eurasian otter
  • Fisher
  • Immunohistochemistry
  • Lutra lutra
  • Lymphoma
  • Martes pennanti

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Intestinal lymphoma of granular lymphocytes in a fisher (martes pennanti) and a eurasian otter (lutra lutra). / Bartlett, Susan L.; Imai, Denise; Trupkiewicz, John G.; Garner, Michael M.; Ogasawara, Seigo; Stokol, Tracy; Kiupel, Matti; Abou-Madi, Noha; Kollias, George V.

In: Journal of Zoo and Wildlife Medicine, Vol. 41, No. 2, 21.06.2010, p. 309-315.

Research output: Contribution to journalArticle

Bartlett, SL, Imai, D, Trupkiewicz, JG, Garner, MM, Ogasawara, S, Stokol, T, Kiupel, M, Abou-Madi, N & Kollias, GV 2010, 'Intestinal lymphoma of granular lymphocytes in a fisher (martes pennanti) and a eurasian otter (lutra lutra)', Journal of Zoo and Wildlife Medicine, vol. 41, no. 2, pp. 309-315. https://doi.org/10.1638/2009-0210R.1
Bartlett, Susan L. ; Imai, Denise ; Trupkiewicz, John G. ; Garner, Michael M. ; Ogasawara, Seigo ; Stokol, Tracy ; Kiupel, Matti ; Abou-Madi, Noha ; Kollias, George V. / Intestinal lymphoma of granular lymphocytes in a fisher (martes pennanti) and a eurasian otter (lutra lutra). In: Journal of Zoo and Wildlife Medicine. 2010 ; Vol. 41, No. 2. pp. 309-315.
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