Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

Mark Underwood

doi:10.1016/j.ypmed.2014.05.010

Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

Mark Underwood

Neonatology

Research output: Contribution to journal › Article

26 Scopus citations

Abstract

New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.

Original language	English (US)
Pages (from-to)	133-137
Number of pages	5
Journal	Preventive Medicine
Volume	65
DOIs	https://doi.org/10.1016/j.ypmed.2014.05.010
State	Published - 2014

Keywords

Acute intestinal inflammation
Akkermansia muciniphila
Bifidobacterium infantis
Colon cancer
Escherichia coli Nissle 1917
Faecalibacterium prausnitzii
Fusobacterium nucleatum
Inflammatory bowel disease
Necrotizing enterocolitis
Obesity

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Epidemiology

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10.1016/j.ypmed.2014.05.010

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Underwood, M. (2014). Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease. Preventive Medicine, 65, 133-137. https://doi.org/10.1016/j.ypmed.2014.05.010

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abstract = "New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.",

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