Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

Mark Underwood

doi:10.1016/j.ypmed.2014.05.010

Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

Mark Underwood

Neonatology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.

Original language	English (US)
Pages (from-to)	133-137
Number of pages	5
Journal	Preventive Medicine
Volume	65
DOIs	https://doi.org/10.1016/j.ypmed.2014.05.010
State	Published - 2014

Keywords

Acute intestinal inflammation
Akkermansia muciniphila
Bifidobacterium infantis
Colon cancer
Escherichia coli Nissle 1917
Faecalibacterium prausnitzii
Fusobacterium nucleatum
Inflammatory bowel disease
Necrotizing enterocolitis
Obesity

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Epidemiology

Access to Document

10.1016/j.ypmed.2014.05.010

Cite this

@article{e087766195424e1993917f44af679c14,

title = "Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease",

abstract = "New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.",

keywords = "Acute intestinal inflammation, Akkermansia muciniphila, Bifidobacterium infantis, Colon cancer, Escherichia coli Nissle 1917, Faecalibacterium prausnitzii, Fusobacterium nucleatum, Inflammatory bowel disease, Necrotizing enterocolitis, Obesity",

author = "Mark Underwood",

year = "2014",

doi = "10.1016/j.ypmed.2014.05.010",

language = "English (US)",

volume = "65",

pages = "133--137",

journal = "Preventive Medicine",

issn = "0091-7435",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Intestinal dysbiosis

T2 - Novel mechanisms by which gut microbes trigger and prevent disease

AU - Underwood, Mark

PY - 2014

Y1 - 2014

N2 - New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.

AB - New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases.

KW - Acute intestinal inflammation

KW - Akkermansia muciniphila

KW - Bifidobacterium infantis

KW - Colon cancer

KW - Escherichia coli Nissle 1917

KW - Faecalibacterium prausnitzii

KW - Fusobacterium nucleatum

KW - Inflammatory bowel disease

KW - Necrotizing enterocolitis

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84901491205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901491205&partnerID=8YFLogxK

U2 - 10.1016/j.ypmed.2014.05.010

DO - 10.1016/j.ypmed.2014.05.010

M3 - Article

C2 - 24857830

AN - SCOPUS:84901491205

VL - 65

SP - 133

EP - 137

JO - Preventive Medicine

JF - Preventive Medicine

SN - 0091-7435

ER -

Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this