Intervillous blood flow in the third trimester gravid rhesus monkey (Macaca mulatta): Use of sonographic contrast agent and harmonic imaging

N. Ragavendra, Alice F Tarantal

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A properly implanted and functioning placenta is essential for the normal outcome of pregnancy. As pregnancy advances, an increasing supply of maternal blood, which reaches the intervillous space of the placenta via the spiral arteries, is necessary for continued growth and development of the fetus. Presumably, deficient blood flow to the intervillous space can lead to placental ischaemia and an unfavourable outcome, such as pre-eclampsia. In this study, we used a primate model, where echocontrast-enhanced harmonic imaging was utilized to demonstrate placental intervillous blood flow without visualization of fetal blood circulation within the chorionic villi. We propose that this technique, which requires further assessment of efficacy and safety prior to use in humans, is a potentially useful non-invasive clinical tool for assessing intervillous blood flow in the third trimester of pregnancy.

Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalPlacenta
Volume22
Issue number2-3
DOIs
StatePublished - 2001

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Third Pregnancy Trimester
Macaca mulatta
Contrast Media
Placenta
Chorionic Villi
Blood Circulation
Pregnancy Outcome
Pre-Eclampsia
Fetal Blood
Growth and Development
Primates
Fetus
Ischemia
Arteries
Mothers
Safety
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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