The effects of nonuniform intertrial intervals on the development and retention of kindled amygdaloid seizures in rats were evaluated. Six consecutive grouped trial sessions (GTSs) consisting of five stimulations with 1-h intertrial intervals each day significantly reduced the average afterdischarge duration and behavioral seizure response of rats previously kindled by single, daily stimulations. Another group was treated with 32 consecutive stimulations at 1-h intervals. The development of kindling in this group was disrupted and only half the group exhibited occasional rank 5 seizures during the hourly stimulations. When the hourly group was subsequently stimulated once daily, kindled seizures were elicited in all animals. These data demonstrate that hourly stimulations or short, massed-trial paradigms disrupt kindled seizures and produce a convulsive response that is different from that produced by a single daily stimulation, suggesting that the pattern of stimulations must be taken into account when interpreting neurophysiologic, biochemical, or pharmacologic data from animals presumably kindled by the stimulations.
ASJC Scopus subject areas