TY - JOUR
T1 - Intertrial intervals and kindled seizures
AU - Peterson, S. L.
AU - Albertson, Timothy E
AU - Stark, L. G.
PY - 1981
Y1 - 1981
N2 - The effects of nonuniform intertrial intervals on the development and retention of kindled amygdaloid seizures in rats were evaluated. Six consecutive grouped trial sessions (GTSs) consisting of five stimulations with 1-h intertrial intervals each day significantly reduced the average afterdischarge duration and behavioral seizure response of rats previously kindled by single, daily stimulations. Another group was treated with 32 consecutive stimulations at 1-h intervals. The development of kindling in this group was disrupted and only half the group exhibited occasional rank 5 seizures during the hourly stimulations. When the hourly group was subsequently stimulated once daily, kindled seizures were elicited in all animals. These data demonstrate that hourly stimulations or short, massed-trial paradigms disrupt kindled seizures and produce a convulsive response that is different from that produced by a single daily stimulation, suggesting that the pattern of stimulations must be taken into account when interpreting neurophysiologic, biochemical, or pharmacologic data from animals presumably kindled by the stimulations.
AB - The effects of nonuniform intertrial intervals on the development and retention of kindled amygdaloid seizures in rats were evaluated. Six consecutive grouped trial sessions (GTSs) consisting of five stimulations with 1-h intertrial intervals each day significantly reduced the average afterdischarge duration and behavioral seizure response of rats previously kindled by single, daily stimulations. Another group was treated with 32 consecutive stimulations at 1-h intervals. The development of kindling in this group was disrupted and only half the group exhibited occasional rank 5 seizures during the hourly stimulations. When the hourly group was subsequently stimulated once daily, kindled seizures were elicited in all animals. These data demonstrate that hourly stimulations or short, massed-trial paradigms disrupt kindled seizures and produce a convulsive response that is different from that produced by a single daily stimulation, suggesting that the pattern of stimulations must be taken into account when interpreting neurophysiologic, biochemical, or pharmacologic data from animals presumably kindled by the stimulations.
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U2 - 10.1016/0014-4886(81)90077-7
DO - 10.1016/0014-4886(81)90077-7
M3 - Article
C2 - 7449891
AN - SCOPUS:0019352065
VL - 71
SP - 144
EP - 153
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -