Interstudy reproducibility of dimensional and functional measurements between cine magnetic resonance studies in the morphologically abnormal left ventricle

Richard C. Semelka, Ernesto Tomei, Stefan Wagner, John Mayo, Gary R Caputo, Margaret O'Sullivan, William W. Parmley, Kanu Chatterjee, Christopher Wolfe, Charles B. Higgins

Research output: Contribution to journalArticle

259 Scopus citations

Abstract

The validity of geometric formulas to derive mass and volumes in the morphologically abnormal left ventricule is problematic. Imaging techniques that are tomographic and therefore inherently three-dimensional should be more reliable and reproducible between studies in such ventricles. Determination of reproducibility between studies is essential to define the limits of an imaging technique for evaluating the response to therapy. Sequential cine magnetic resonance (MR) studies were performed on patients with dilated cardiomyopathy (n=11) and left ventricular hypertrophy (n=8) within a short interval in order to assess interstudy reproducbility. Left ventricular mass, volumes, ejection fraction, and end-systolic wall stress were determined by two independent observers. Between studies, left ventricular mass was highly reproducible for hypertrophied and dilated ventricles, with percent variability less than 6%. Ejection fraction and end-diastolic volume showed close reproducibility between studies, with percent variability less than 5%. End-systolic volume varied by 4.3% and 4.5% in dilated cardiomyopathy and 8.4% and 7.2% in left ventricular hypertrophy for the two observers. End-systolic wall stress, which is derived from multiple measurements, varied the greatest, with percent variability of 17.2% and 15.7% in dilated cardiomyopathy and 14.8% and 13% in left ventricular hypertrophy, respectively. The results of this study demonstrate that mass, volume, and functional measurements are reproducible in morphologically abnormal ventricles.

Original languageEnglish (US)
Pages (from-to)1367-1373
Number of pages7
JournalAmerican Heart Journal
Volume119
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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