Interstitial lung disease in systemic sclerosis

Gurtej S. Cheema, Francisco P. Quismorio

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Systemic sclerosis is a multisystem disorder of unknown etiology and involves organ systems such as the skin, peripheral vasculature, gastrointestinal tract, kidney, heart, and the lungs is observed quite frequently. In this review, we discuss the development of interstitial lung disease, one of the common pulmonary manifestations and a major cause of mortality and morbidity in this disorder. It is, however, under-recognized and diagnosed late in the course of the illness. Early use of pulmonary function tests followed by bronchoalveolar lavage in appropriate cases helps in early diagnosis. Recent studies emphasize the role of various profibrotic and inflammatory cytokines both locally in the lung and systemically in its pathogenesis. Treatment is helpful in arresting the progression if initiated early. Cyclophosphamide with or without corticosteroids given orally or as intravenous pulse may be helpful.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalCurrent Opinion in Pulmonary Medicine
Volume7
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Systemic Scleroderma
Interstitial Lung Diseases
Lung
Respiratory Function Tests
Bronchoalveolar Lavage
Cyclophosphamide
Gastrointestinal Tract
Early Diagnosis
Adrenal Cortex Hormones
Cytokines
Morbidity
Kidney
Skin
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Interstitial lung disease in systemic sclerosis. / Cheema, Gurtej S.; Quismorio, Francisco P.

In: Current Opinion in Pulmonary Medicine, Vol. 7, No. 5, 2001, p. 283-290.

Research output: Contribution to journalArticle

Cheema, Gurtej S. ; Quismorio, Francisco P. / Interstitial lung disease in systemic sclerosis. In: Current Opinion in Pulmonary Medicine. 2001 ; Vol. 7, No. 5. pp. 283-290.
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