Interpretation by clinicians of probability expressions in cytology reports and effect on clinical decision-making

Mary M Christopher, C. S. Hotz, S. M. Shelly, P. D. Pion

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Cytology often is used to obtain a diagnosis, such as that of malignant neoplasia. When a diagnosis is uncertain, pathologists often express probability using qualitative terms, such as "probable," that have imprecise meanings. Hypothesis: Terms expressing probability are interpreted variably by veterinary practitioners and affect decisions regarding treatment and euthanasia. Animals: None. Methods: An online survey of members of the Veterinary Information Network was conducted. Veterinarians were asked to assign percentage probabilities to 18 modifiers of a diagnosis of lymphoma. They also were asked to select their most likely clinical action based on a diagnosis of lymphoma qualified one of 4 modifiers. Results were analyzed using descriptive and nonparametric methods. Percentage probabilities were analyzed by ANOVA after variance stabilization. Results: For 871 valid surveys, probabilities assigned to the 18 modifiers overlapped substantially, with medians (interquartile range) of 50% (50-70%) for "possible," 66% (66-85%) for "probable," and 70% (70-90%) for "consistent with." More (P < 001) veterinarians (50.4%) chose to initiate treatment with a diagnosis of "consistent with lymphoma" as compared with "probable" (14.6%) or "possible" (1.6%) lymphoma. For clients considering euthanasia if the diagnosis was cancer, more (P < 001) veterinarians recommended euthanasia with a diagnosis of "consistent with lymphoma" (62.5%) as compared with "probable" (35.3%), or "possible" (2.0%) lymphoma. Conclusions and Clinical Importance: Probability expressions are interpreted variably yet have a major impact on clinical decision-making, including the decision to recommend euthanasia. Standardized terminology could improve decision-making and enhance clinical outcome.

Original languageEnglish (US)
Pages (from-to)496-503
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume24
Issue number3
DOIs
StatePublished - May 2010

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lymphoma
cell biology
Cell Biology
decision making
Lymphoma
euthanasia
Euthanasia
veterinarians
Veterinarians
information networks
neoplasms
terminology
Information Services
Clinical Decision-Making
Terminology
analysis of variance
Neoplasms
Analysis of Variance
methodology
Therapeutics

Keywords

  • Clinical pathology
  • Decision support
  • Evidence-based medicine
  • Oncology diagnosis
  • Uncertainty

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Interpretation by clinicians of probability expressions in cytology reports and effect on clinical decision-making. / Christopher, Mary M; Hotz, C. S.; Shelly, S. M.; Pion, P. D.

In: Journal of Veterinary Internal Medicine, Vol. 24, No. 3, 05.2010, p. 496-503.

Research output: Contribution to journalArticle

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