Abstract
Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca 2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-112 |
| Number of pages | 18 |
| Journal | Biophysical Journal |
| Volume | 91 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
Cite this
Interplay of ryanodine receptor distribution and calcium dynamics. / Izu, Leighton T; Means, Shawn A.; Shadid, John N.; Chen-Izu, Ye; Balke, C. William.
In: Biophysical Journal, Vol. 91, No. 1, 2006, p. 95-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interplay of ryanodine receptor distribution and calcium dynamics
AU - Izu, Leighton T
AU - Means, Shawn A.
AU - Shadid, John N.
AU - Chen-Izu, Ye
AU - Balke, C. William
PY - 2006
Y1 - 2006
N2 - Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca 2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.
AB - Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca 2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.
UR - http://www.scopus.com/inward/record.url?scp=33745756830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745756830&partnerID=8YFLogxK
U2 - 10.1529/biophysj.105.077214
DO - 10.1529/biophysj.105.077214
M3 - Article
C2 - 16603499
AN - SCOPUS:33745756830
VL - 91
SP - 95
EP - 112
JO - Biophysical Journal
JF - Biophysical Journal
SN - 0006-3495
IS - 1
ER -