Interplay of ryanodine receptor distribution and calcium dynamics

Leighton T Izu; Shawn A. Means; John N. Shadid; Ye Chen-Izu; C. William Balke

doi:10.1529/biophysj.105.077214

Interplay of ryanodine receptor distribution and calcium dynamics

Leighton T Izu, Shawn A. Means, John N. Shadid, Ye Chen-Izu, C. William Balke

Research output: Contribution to journal › Article

78 Scopus citations

Abstract

Spontaneously generated calcium (Ca²⁺) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca²⁺ waves also serve the physiological function of mediating global Ca²⁺ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca²⁺ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca ²⁺ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca²⁺ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca²⁺ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.

Original language	English (US)
Pages (from-to)	95-112
Number of pages	18
Journal	Biophysical Journal
Volume	91
Issue number	1
DOIs	https://doi.org/10.1529/biophysj.105.077214
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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Izu, L. T., Means, S. A., Shadid, J. N., Chen-Izu, Y., & Balke, C. W. (2006). Interplay of ryanodine receptor distribution and calcium dynamics. Biophysical Journal, 91(1), 95-112. https://doi.org/10.1529/biophysj.105.077214

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