Abstract
Asubset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons. The eight members of this subfamily were originally all designated as calcium-activated channels. More recent studies have clarified the gating mechanisms for these channels and have documented that not allmembers are sensitive to calcium. This article describes themolecular relationships between these channels and provides an introduction to their functional properties. It also introduces a new nomenclature that differentiates between calcium- and sodium-activated potassium channels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Pharmacological Reviews |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
Cite this
International union of basic and clinical pharmacology. C. Nomenclature and properties of calcium-activated and sodium-activated potassium channels. / Kaczmarek, Leonard K.; Aldrich, Richard W.; Chandy, K. George; Grissmer, Stephan; Wei, Aguan D.; Wulff, Heike.
In: Pharmacological Reviews, Vol. 69, No. 1, 01.01.2017, p. 1-11.Research output: Contribution to journal › Article
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TY - JOUR
T1 - International union of basic and clinical pharmacology. C. Nomenclature and properties of calcium-activated and sodium-activated potassium channels
AU - Kaczmarek, Leonard K.
AU - Aldrich, Richard W.
AU - Chandy, K. George
AU - Grissmer, Stephan
AU - Wei, Aguan D.
AU - Wulff, Heike
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Asubset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons. The eight members of this subfamily were originally all designated as calcium-activated channels. More recent studies have clarified the gating mechanisms for these channels and have documented that not allmembers are sensitive to calcium. This article describes themolecular relationships between these channels and provides an introduction to their functional properties. It also introduces a new nomenclature that differentiates between calcium- and sodium-activated potassium channels.
AB - Asubset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons. The eight members of this subfamily were originally all designated as calcium-activated channels. More recent studies have clarified the gating mechanisms for these channels and have documented that not allmembers are sensitive to calcium. This article describes themolecular relationships between these channels and provides an introduction to their functional properties. It also introduces a new nomenclature that differentiates between calcium- and sodium-activated potassium channels.
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UR - http://www.scopus.com/inward/citedby.url?scp=85005976241&partnerID=8YFLogxK
U2 - 10.1124/pr.116.012864
DO - 10.1124/pr.116.012864
M3 - Article
VL - 69
SP - 1
EP - 11
JO - Pharmacological Reviews
JF - Pharmacological Reviews
SN - 0031-6997
IS - 1
ER -