International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19

Verena Börger, Daniel J. Weiss, Johnathon D. Anderson, Francesc E. Borràs, Benedetta Bussolati, David R.F. Carter, Massimo Dominici, Juan M. Falcón-Pérez, Mario Gimona, Andrew F. Hill, Andrew M. Hoffman, Dominique de Kleijn, Bruce L. Levine, Rebecca Lim, Jan Lötvall, S. Alex Mitsialis, Marta Monguió-Tortajada, Maurizio Muraca, Rienk Nieuwland, Anna NowocinLorraine O'Driscoll, Luis A. Ortiz, Donald G. Phinney, Ilona Reischl, Eva Rohde, Ralf Sanzenbacher, Clotilde Théry, Wei Seong Toh, Kenneth W. Witwer, Sai Kiang Lim, Bernd Giebel

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalCytotherapy
Volume22
Issue number9
DOIs
StatePublished - Sep 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Genetics(clinical)
  • Cell Biology
  • Cancer Research
  • Transplantation

Fingerprint Dive into the research topics of 'International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19'. Together they form a unique fingerprint.

Cite this