Abstract
A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7 %) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are ≤5 cM and only 3% >20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-15 |
| Number of pages | 11 |
| Journal | Cytogenetic and Genome Research |
| Volume | 111 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2005 |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)
Cite this
International equine gene mapping workshop report : A comprehensive linkage map constructed with data from new markers and by merging four mapping resources. / Penedo, Cecilia; Millon, L. V.; Bernoco, D.; Bailey, E.; Binns, M.; Cholewinski, G.; Ellis, N.; Flynn, J.; Gralak, B.; Guthrie, A.; Hasegawa, T.; Lindgren, G.; Lyons, Leslie A; Røed, K. H.; Swinburne, J. E.; Tozaki, T.
In: Cytogenetic and Genome Research, Vol. 111, No. 1, 2005, p. 5-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - International equine gene mapping workshop report
T2 - A comprehensive linkage map constructed with data from new markers and by merging four mapping resources
AU - Penedo, Cecilia
AU - Millon, L. V.
AU - Bernoco, D.
AU - Bailey, E.
AU - Binns, M.
AU - Cholewinski, G.
AU - Ellis, N.
AU - Flynn, J.
AU - Gralak, B.
AU - Guthrie, A.
AU - Hasegawa, T.
AU - Lindgren, G.
AU - Lyons, Leslie A
AU - Røed, K. H.
AU - Swinburne, J. E.
AU - Tozaki, T.
PY - 2005
Y1 - 2005
N2 - A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7 %) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are ≤5 cM and only 3% >20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
AB - A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7 %) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are ≤5 cM and only 3% >20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
UR - http://www.scopus.com/inward/record.url?scp=23844540295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23844540295&partnerID=8YFLogxK
U2 - 10.1159/000085664
DO - 10.1159/000085664
M3 - Article
C2 - 16093715
AN - SCOPUS:23844540295
VL - 111
SP - 5
EP - 15
JO - Cytogenetic and Genome Research
JF - Cytogenetic and Genome Research
SN - 1424-8581
IS - 1
ER -