International equine gene mapping workshop report

A comprehensive linkage map constructed with data from new markers and by merging four mapping resources

Cecilia Penedo, L. V. Millon, D. Bernoco, E. Bailey, M. Binns, G. Cholewinski, N. Ellis, J. Flynn, B. Gralak, A. Guthrie, T. Hasegawa, G. Lindgren, Leslie A Lyons, K. H. Røed, J. E. Swinburne, T. Tozaki

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7 %) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are ≤5 cM and only 3% >20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalCytogenetic and Genome Research
Volume111
Issue number1
DOIs
StatePublished - 2005

Fingerprint

Chromosome Mapping
Horses
Radiation Hybrid Mapping
Education
Sweden
Microsatellite Repeats
Chromosomes
Genotype
Genome
Health
Genes
United Kingdom
Datasets

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

International equine gene mapping workshop report : A comprehensive linkage map constructed with data from new markers and by merging four mapping resources. / Penedo, Cecilia; Millon, L. V.; Bernoco, D.; Bailey, E.; Binns, M.; Cholewinski, G.; Ellis, N.; Flynn, J.; Gralak, B.; Guthrie, A.; Hasegawa, T.; Lindgren, G.; Lyons, Leslie A; Røed, K. H.; Swinburne, J. E.; Tozaki, T.

In: Cytogenetic and Genome Research, Vol. 111, No. 1, 2005, p. 5-15.

Research output: Contribution to journalArticle

Penedo, C, Millon, LV, Bernoco, D, Bailey, E, Binns, M, Cholewinski, G, Ellis, N, Flynn, J, Gralak, B, Guthrie, A, Hasegawa, T, Lindgren, G, Lyons, LA, Røed, KH, Swinburne, JE & Tozaki, T 2005, 'International equine gene mapping workshop report: A comprehensive linkage map constructed with data from new markers and by merging four mapping resources', Cytogenetic and Genome Research, vol. 111, no. 1, pp. 5-15. https://doi.org/10.1159/000085664
Penedo, Cecilia ; Millon, L. V. ; Bernoco, D. ; Bailey, E. ; Binns, M. ; Cholewinski, G. ; Ellis, N. ; Flynn, J. ; Gralak, B. ; Guthrie, A. ; Hasegawa, T. ; Lindgren, G. ; Lyons, Leslie A ; Røed, K. H. ; Swinburne, J. E. ; Tozaki, T. / International equine gene mapping workshop report : A comprehensive linkage map constructed with data from new markers and by merging four mapping resources. In: Cytogenetic and Genome Research. 2005 ; Vol. 111, No. 1. pp. 5-15.
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