Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.

J. A. Wisniewski, D. E. Moody, B. D. Hammock, L. R. Shull

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalJournal of Animal Science
Volume64
Issue number1
StatePublished - Jan 1987
Externally publishedYes

Fingerprint

Xenobiotics
xenobiotics
Goats
Sheep
goats
enzyme activity
sheep
liver
Liver
cattle
Enzymes
Aminopyrine N-Demethylase
7-Alkoxycoumarin O-Dealkylase
epoxide hydrolase
Epoxide Hydrolases
aldrin
NADPH-Ferrihemoprotein Reductase
Carboxylesterase
stilbenes
NADH dehydrogenase

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Wisniewski, J. A., Moody, D. E., Hammock, B. D., & Shull, L. R. (1987). Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. Journal of Animal Science, 64(1), 210-215.

Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. / Wisniewski, J. A.; Moody, D. E.; Hammock, B. D.; Shull, L. R.

In: Journal of Animal Science, Vol. 64, No. 1, 01.1987, p. 210-215.

Research output: Contribution to journalArticle

Wisniewski, JA, Moody, DE, Hammock, BD & Shull, LR 1987, 'Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.', Journal of Animal Science, vol. 64, no. 1, pp. 210-215.
Wisniewski, J. A. ; Moody, D. E. ; Hammock, B. D. ; Shull, L. R. / Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. In: Journal of Animal Science. 1987 ; Vol. 64, No. 1. pp. 210-215.
@article{6c582a66e97a47fbbcb98a21a211a0f0,
title = "Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.",
abstract = "Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.",
author = "Wisniewski, {J. A.} and Moody, {D. E.} and Hammock, {B. D.} and Shull, {L. R.}",
year = "1987",
month = "1",
language = "English (US)",
volume = "64",
pages = "210--215",
journal = "Journal of Animal Science",
issn = "0021-8812",
publisher = "American Society of Animal Science",
number = "1",

}

TY - JOUR

T1 - Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.

AU - Wisniewski, J. A.

AU - Moody, D. E.

AU - Hammock, B. D.

AU - Shull, L. R.

PY - 1987/1

Y1 - 1987/1

N2 - Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.

AB - Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.

UR - http://www.scopus.com/inward/record.url?scp=0023174746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023174746&partnerID=8YFLogxK

M3 - Article

C2 - 3818484

AN - SCOPUS:0023174746

VL - 64

SP - 210

EP - 215

JO - Journal of Animal Science

JF - Journal of Animal Science

SN - 0021-8812

IS - 1

ER -