Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.

J. A. Wisniewski, D. E. Moody, B. D. Hammock, L. R. Shull

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. Among species, several activities differed (P less than .05), with cattle livers generally having lower values than sheep or goats.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalJournal of Animal Science
Volume64
Issue number1
StatePublished - Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology

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    Wisniewski, J. A., Moody, D. E., Hammock, B. D., & Shull, L. R. (1987). Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. Journal of Animal Science, 64(1), 210-215.