Interleukins 7 and 12 are expressed in head and neck squamous cancer

V. Paleri, A. Pulimood, G. R. Davies, M. A. Birchall

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated tumour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalClinical Otolaryngology and Allied Sciences
Volume26
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Head and neck cancer
  • Interleukin 12
  • Interleukin 7

ASJC Scopus subject areas

  • Otorhinolaryngology

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