Interleukins 7 and 12 are expressed in head and neck squamous cancer

V. Paleri, A. Pulimood, G. R. Davies, M. A. Birchall

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated tumour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalClinical Otolaryngology and Allied Sciences
Volume26
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Interleukin-7
Interleukin-12
Head and Neck Neoplasms
Squamous Cell Neoplasms
Head
Cellular Immunity
Neoplasms
Immunohistochemistry
Staining and Labeling
Survival

Keywords

  • Head and neck cancer
  • Interleukin 12
  • Interleukin 7

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Interleukins 7 and 12 are expressed in head and neck squamous cancer. / Paleri, V.; Pulimood, A.; Davies, G. R.; Birchall, M. A.

In: Clinical Otolaryngology and Allied Sciences, Vol. 26, No. 4, 2001, p. 302-306.

Research output: Contribution to journalArticle

Paleri, V. ; Pulimood, A. ; Davies, G. R. ; Birchall, M. A. / Interleukins 7 and 12 are expressed in head and neck squamous cancer. In: Clinical Otolaryngology and Allied Sciences. 2001 ; Vol. 26, No. 4. pp. 302-306.
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