Abstract
Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated tumour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 302-306 |
| Number of pages | 5 |
| Journal | Clinical Otolaryngology and Allied Sciences |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Head and neck cancer
- Interleukin 12
- Interleukin 7
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Interleukins 7 and 12 are expressed in head and neck squamous cancer. / Paleri, V.; Pulimood, A.; Davies, G. R.; Birchall, M. A.
In: Clinical Otolaryngology and Allied Sciences, Vol. 26, No. 4, 2001, p. 302-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukins 7 and 12 are expressed in head and neck squamous cancer
AU - Paleri, V.
AU - Pulimood, A.
AU - Davies, G. R.
AU - Birchall, M. A.
PY - 2001
Y1 - 2001
N2 - Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated tumour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.
AB - Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated tumour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.
KW - Head and neck cancer
KW - Interleukin 12
KW - Interleukin 7
UR - http://www.scopus.com/inward/record.url?scp=0034791925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034791925&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2273.2001.00475.x
DO - 10.1046/j.1365-2273.2001.00475.x
M3 - Article
C2 - 11559342
AN - SCOPUS:0034791925
VL - 26
SP - 302
EP - 306
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
SN - 1749-4478
IS - 4
ER -