Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice

Michael P. McLane, Angela Franciska Haczku, Matthijs Van De Rijn, Christine Weiss, Veronica Ferrante, Dorothy MacDonald, Jean Christophe Renauld, Nicholas C. Nicolaides, Kenneth J. Holroyd, Roy C. Levitt

Research output: Contribution to journalArticle

163 Scopus citations

Abstract

Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume19
Issue number5
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pulmonary and Respiratory Medicine

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    McLane, M. P., Haczku, A. F., Van De Rijn, M., Weiss, C., Ferrante, V., MacDonald, D., Renauld, J. C., Nicolaides, N. C., Holroyd, K. J., & Levitt, R. C. (1998). Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. American Journal of Respiratory Cell and Molecular Biology, 19(5), 713-720.