Abstract
Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 713-720 |
| Number of pages | 8 |
| Journal | American Journal of Respiratory Cell and Molecular Biology |
| Volume | 19 |
| Issue number | 5 |
| State | Published - 1998 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Pulmonary and Respiratory Medicine
Cite this
Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. / McLane, Michael P.; Haczku, Angela Franciska; Van De Rijn, Matthijs; Weiss, Christine; Ferrante, Veronica; MacDonald, Dorothy; Renauld, Jean Christophe; Nicolaides, Nicholas C.; Holroyd, Kenneth J.; Levitt, Roy C.
In: American Journal of Respiratory Cell and Molecular Biology, Vol. 19, No. 5, 1998, p. 713-720.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice
AU - McLane, Michael P.
AU - Haczku, Angela Franciska
AU - Van De Rijn, Matthijs
AU - Weiss, Christine
AU - Ferrante, Veronica
AU - MacDonald, Dorothy
AU - Renauld, Jean Christophe
AU - Nicolaides, Nicholas C.
AU - Holroyd, Kenneth J.
AU - Levitt, Roy C.
PY - 1998
Y1 - 1998
N2 - Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.
AB - Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=18344401643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18344401643&partnerID=8YFLogxK
M3 - Article
C2 - 9806735
AN - SCOPUS:18344401643
VL - 19
SP - 713
EP - 720
JO - American Journal of Respiratory Cell and Molecular Biology
JF - American Journal of Respiratory Cell and Molecular Biology
SN - 1044-1549
IS - 5
ER -