Interleukin-6 polymorphism is associated with more aggressive prostate cancer

Dongfeng Tan, Xiuxian Wu, Min Hou, Soo Ok Lee, Wei Lou, Jianmin Wang, Bagirathan Janarthan, Sujatha Nallapareddy, Donald L. Trump, Allen C Gao

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Purpose: Interleukin-6 (IL-6) has an important role during prostate cancer progression and IL-6 levels in the serum of patients with hormone refractory and metastatic prostate cancer are significantly increased compared with those in patients with hormone sensitive and localized prostate cancer. The G>G polymorphism at position -174 in the promoter of the IL-6 gene has been associated with differences in IL-6 transcription in vitro and IL-6 protein levels in vivo. We determined the association of IL-6 polymorphism with prostate cancer progression. Materials and Methods: We examined the association of IL-6 polymorphism with the risk of advanced disease in 95 patients with different stages of prostate cancer using the tetra-primer polymerase chain reaction genotyping method. Results: We found that the -174G>C genotype of IL-6 gene was associated with an overall increased risk of advanced prostate cancer. A strong association between this genotype and Gleason score was observed at the -174G>C locus of the IL-6 gene (p <0.001). The distribution of this genotype was also significantly different between stages T3-T4 and T1-T2 tumors (p <0.001). In addition, the IL-6 genotype was linked with vascular invasion (p = 0.024), seminal vesicle involvement (p = 0.006) and capsular invasion (p <0.001). Furthermore, the -174G>C genotype of the IL-6 gene was significantly associated with increased serum prostate specific antigen (p = 0.004) and with recurrent prostate cancer compared with GG homozygotes (p = 0.027). Conclusions: These data demonstrate a strong association of the -174G>C polymorphism of the IL-6 gene with the aggressiveness and recurrence of prostate cancer, suggesting that genetic predisposition of genetic differences in the human IL-6 gene could be linked to the risk of recurrent prostate cancer.

Original languageEnglish (US)
Pages (from-to)753-756
Number of pages4
JournalJournal of Urology
Issue number2
StatePublished - Aug 2005
Externally publishedYes


  • Interleukin-6
  • Neoplasm recurrence
  • Polymorphism, genetic
  • Prostate
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology


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