Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s

Hernan Valdez, Ronald Mitsuyasu, Alan Landay, Anne D. Sevin, Ellen S. Chan, John Spritzler, Spyros A. Kalams, Richard B Pollard, John Fahey, Lawrence Fox, Ann Namkung, Scharla Estep, Ronald Moss, David Sahner, Michael M. Lederman

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalJournal of Infectious Diseases
Volume187
Issue number2
DOIs
StatePublished - Jan 15 2003

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Valdez, H., Mitsuyasu, R., Landay, A., Sevin, A. D., Chan, E. S., Spritzler, J., Kalams, S. A., Pollard, R. B., Fahey, J., Fox, L., Namkung, A., Estep, S., Moss, R., Sahner, D., & Lederman, M. M. (2003). Interleukin-2 increases CD4+ lymphocyte numbers but does not enhance responses to immunization: Results of A5046s. Journal of Infectious Diseases, 187(2), 320-325. https://doi.org/10.1086/346056