Interleukin-17 family and IL-17 receptors

T. A. Moseley, Dominik R Haudenschild, L. Rose, A Hari Reddi

Research output: Contribution to journalArticle

667 Scopus citations

Abstract

Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.

Original languageEnglish (US)
Pages (from-to)155-174
Number of pages20
JournalCytokine and Growth Factor Reviews
Volume14
Issue number2
DOIs
StatePublished - Apr 2003

Keywords

  • Cancer
  • Cartilage
  • Interleukin-17
  • Prostate
  • Receptors
  • T-cells

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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