Abstract
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 155-174 |
| Number of pages | 20 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2003 |
Fingerprint
Keywords
- Cancer
- Cartilage
- Interleukin-17
- Prostate
- Receptors
- T-cells
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Interleukin-17 family and IL-17 receptors. / Moseley, T. A.; Haudenschild, Dominik R; Rose, L.; Reddi, A Hari.
In: Cytokine and Growth Factor Reviews, Vol. 14, No. 2, 04.2003, p. 155-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-17 family and IL-17 receptors
AU - Moseley, T. A.
AU - Haudenschild, Dominik R
AU - Rose, L.
AU - Reddi, A Hari
PY - 2003/4
Y1 - 2003/4
N2 - Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.
AB - Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.
KW - Cancer
KW - Cartilage
KW - Interleukin-17
KW - Prostate
KW - Receptors
KW - T-cells
UR - http://www.scopus.com/inward/record.url?scp=0037379607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037379607&partnerID=8YFLogxK
U2 - 10.1016/S1359-6101(03)00002-9
DO - 10.1016/S1359-6101(03)00002-9
M3 - Article
C2 - 12651226
AN - SCOPUS:0037379607
VL - 14
SP - 155
EP - 174
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 2
ER -