Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities

Alan Menter, Gerald G. Krueger, So Yeon Paek, Dario Kivelevitch, Iannis E. Adamopoulos, Richard G. Langley

Research output: Contribution to journalReview articlepeer-review

Abstract

Psoriasis is an immune-mediated inflammatory skin disease associated with numerous inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL)-23/IL-17 axis plays a central role in the immunopathogenesis of psoriasis and related comorbidities by acting to stimulate keratinocyte hyperproliferation and feed-forwarding circuits of perpetual T cell-mediated inflammation. IL-17 plays an important role in the downstream portion of the psoriatic inflammatory cascade. This review discusses the distinct mechanisms of action of IL-17 and IL-23 in the immunopathogenesis of psoriasis and related comorbidities plus the significant therapeutic benefits of selectively inhibiting these cytokines in patients with moderate to severe plaque psoriasis.

Original languageEnglish (US)
Pages (from-to)385-400
Number of pages16
JournalDermatology and Therapy
Volume11
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Comorbidities
  • Cytokines
  • Inflammation
  • Interleukin-17
  • Interleukin-23
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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