Interleukin 12 and indomethacin exert a synergistic, angiogenesis- dependent antitumor activity in mice

Jakub Goła̧b, Katarzyna Kozar, Rafał Kamiński, Anna Czajka, Maria Marczak, Tomasz Świtaj, Adam Giermasz, Tomasz Stokłosa, Witold Lasek, Radosław Zagozdzon, Krzysztof Mucha, Marek Jakóbisiak

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence and mortality from colorectal cancer. It has recently been demonstrated that these drugs are capable of suppressing the production of pro-angiogenic factors from tumor cells. The mechanisms of antitumor action of interleukin 12 include the enforced secretion of anti-angiogenic factors and stimulation of antitumor immunity. Therefore, we hypothesized that the combination of a model nonsteroidal anti-inflammatory drug - indomethacin and interleukin 12 would result in enhanced angiogenesis-dependent antitumor effects against a colon-26 carcinoma cells transplanted into syngeneic mice. As expected the combined administration of both agents simultaneously resulted in a strengthened antitumor activity that was manifested as a retardation of tumor growth and prolongation of mouse survival. Importantly some mice were completely cured after the combined treatment. As administration of interleukin 12 and indomethacin resulted in enhanced inhibition of angiogenesis it seems possible that prevention of new blood vessel formation is one of the mechanisms responsible for the observed antitumor effects.

Original languageEnglish (US)
Pages (from-to)1223-1230
Number of pages8
JournalLife Sciences
Volume66
Issue number13
DOIs
StatePublished - Feb 11 2000
Externally publishedYes

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Keywords

  • Colon cancer
  • Indomethacin
  • Interleukin 12

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Goła̧b, J., Kozar, K., Kamiński, R., Czajka, A., Marczak, M., Świtaj, T., Giermasz, A., Stokłosa, T., Lasek, W., Zagozdzon, R., Mucha, K., & Jakóbisiak, M. (2000). Interleukin 12 and indomethacin exert a synergistic, angiogenesis- dependent antitumor activity in mice. Life Sciences, 66(13), 1223-1230. https://doi.org/10.1016/S0024-3205(00)00427-6