Intergenerational effects of mutations in the fragile X mental retardation 1 gene. Fragile X: A model of X-linked mental retardation and neurodegeneration

Mariya Borodyanskaya, Sarah Coffey, Michele Y. Ono, Randi J Hagerman

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Introduction: There have been remarkable advances in genetics over the past decade including the sequencing of the human genome which was completed in 2003, 50 years after the discovery of the double-helix structure of DNA by Watson and Crick (Valle, 2004). These advances have furthered our understanding of many forms of mental retardation, including X-linked mental retardation of which fragile X syndrome (FXS) is the most common type. There are approximately 30, 000 genes in the human genome, and approximately 1000 genes on the X chromosome. Over 200 of these genes on the X chromosome have been associated with mental retardation. The X chromosome has more genes associated with mental retardation than any other chromosome. Approximately 20–25% of all cases of mental retardation are X-linked. Because males only have one X chromosome, they are much more vulnerable to the effects of an abnormal gene on the chromosome. There are approximately 20% more males with mental retardation than females in the general population. In this chapter we will review the most common inherited cause of mental retardation and neurodegeneration; fragile X associated tremor/ataxia syndrome (FXTAS), the most common cause of ataxia in those over 50 years of age; and the fragile X mental retardation 1 gene (FMR1), the most common gene associated with X-linked mental retardation.

Original languageEnglish (US)
Title of host publicationGenes, Brain and Development: The Neurocognition of Genetic Disorders
PublisherCambridge University Press
Pages3-18
Number of pages16
Volume9780521685368
ISBN (Print)9780511770708, 9780521685368
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Psychology(all)

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    Borodyanskaya, M., Coffey, S., Ono, M. Y., & Hagerman, R. J. (2010). Intergenerational effects of mutations in the fragile X mental retardation 1 gene. Fragile X: A model of X-linked mental retardation and neurodegeneration. In Genes, Brain and Development: The Neurocognition of Genetic Disorders (Vol. 9780521685368, pp. 3-18). Cambridge University Press. https://doi.org/10.1017/CBO9780511770708.002