Interferon-triggered transcriptional cascades in the oligodendroglial lineage: A comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes

Takayuki Ito, Makoto Horiuchi, Aki Itoh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Interferon-γ induces major histocompatibility complex class II (MHC-II) in proliferating oligodendroglial progenitor cells (OPC), but to a much lesser extent in mature oligodendrocytes. Interferon-β has virtually no effects on MHC-II induction even in OPC. Interferon-γ-mediated transcriptional induction of CIITA, a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation. The distinct difference in MHC-II induction between interferon-γ and interferon-β is attributed to transient interferon-β-mediated activation of STAT1-IRF1 signaling compared to the sustained interferon-γ-mediated activation.

Original languageEnglish (US)
Pages (from-to)53-64
Number of pages12
JournalJournal of Neuroimmunology
Volume212
Issue number1-2
DOIs
StatePublished - Jul 25 2009

Fingerprint

Histocompatibility Antigens Class II
Oligodendroglia
Interferons
Stem Cells
Major Histocompatibility Complex

Keywords

  • CIITA
  • DNA methylation
  • Interferon
  • IRF
  • MHC
  • Oligodendroglial lineage

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

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title = "Interferon-triggered transcriptional cascades in the oligodendroglial lineage: A comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes",
abstract = "Interferon-γ induces major histocompatibility complex class II (MHC-II) in proliferating oligodendroglial progenitor cells (OPC), but to a much lesser extent in mature oligodendrocytes. Interferon-β has virtually no effects on MHC-II induction even in OPC. Interferon-γ-mediated transcriptional induction of CIITA, a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation. The distinct difference in MHC-II induction between interferon-γ and interferon-β is attributed to transient interferon-β-mediated activation of STAT1-IRF1 signaling compared to the sustained interferon-γ-mediated activation.",
keywords = "CIITA, DNA methylation, Interferon, IRF, MHC, Oligodendroglial lineage",
author = "Takayuki Ito and Makoto Horiuchi and Aki Itoh",
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T1 - Interferon-triggered transcriptional cascades in the oligodendroglial lineage

T2 - A comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes

AU - Ito, Takayuki

AU - Horiuchi, Makoto

AU - Itoh, Aki

PY - 2009/7/25

Y1 - 2009/7/25

N2 - Interferon-γ induces major histocompatibility complex class II (MHC-II) in proliferating oligodendroglial progenitor cells (OPC), but to a much lesser extent in mature oligodendrocytes. Interferon-β has virtually no effects on MHC-II induction even in OPC. Interferon-γ-mediated transcriptional induction of CIITA, a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation. The distinct difference in MHC-II induction between interferon-γ and interferon-β is attributed to transient interferon-β-mediated activation of STAT1-IRF1 signaling compared to the sustained interferon-γ-mediated activation.

AB - Interferon-γ induces major histocompatibility complex class II (MHC-II) in proliferating oligodendroglial progenitor cells (OPC), but to a much lesser extent in mature oligodendrocytes. Interferon-β has virtually no effects on MHC-II induction even in OPC. Interferon-γ-mediated transcriptional induction of CIITA, a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation. The distinct difference in MHC-II induction between interferon-γ and interferon-β is attributed to transient interferon-β-mediated activation of STAT1-IRF1 signaling compared to the sustained interferon-γ-mediated activation.

KW - CIITA

KW - DNA methylation

KW - Interferon

KW - IRF

KW - MHC

KW - Oligodendroglial lineage

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