Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication

Timothy D. Carroll, Shannon R. Matzinger, Meritxell Genescà, Linda Fritts, Roxana Colòn, Michael B. McChesney, Chris J Miller

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

To determine the relationship between influenza A virus replication and innate antiviral immune responses, rhesus monkeys were given oseltamivir before influenza A/Memphis/7/01 (H1N1) challenge. We found that oseltamivir treatment significantly reduced viral replication in the trachea (p < 0.029). Further, in the trachea of both treated and untreated monkeys the mRNA levels of most innate antiviral molecules in the IFN-αβ pathway were dramatically increased by 24 h postinfection. However, the mRNA level of a single IFN-stimulated gene, MxA (myxovirus resistance A), the IFN-stimulated gene known to be critical in blocking influenza virus replication, was significantly lower in the tracheal lavages of untreated monkeys than in the oseltamivir-treated monkeys (p = 0.05). These results demonstrate for the first time that uncontrolled influenza A virus replication actively suppresses MxA gene expression and emphasize the critical role of innate immunity in controlling influenza virus replication in vivo.

Original languageEnglish (US)
Pages (from-to)2385-2395
Number of pages11
JournalJournal of Immunology
Volume180
Issue number4
StatePublished - Feb 15 2008

ASJC Scopus subject areas

  • Immunology

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