Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott G. Hansen, Michael K. Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A Roberts

Research output: Contribution to journalArticle

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalJournal of medical primatology
Volume48
Issue number4
DOIs
StatePublished - Aug 1 2019

Fingerprint

Mycobacterium tuberculosis complex
Macaca mulatta
interferon-gamma
Mycobacterium tuberculosis
Primates
Interferon-gamma
immune response
blood
assays
Infection
infection
animals
testing
sampling

Keywords

  • cell-mediated immune response (CMI)
  • interferon-gamma release assay (IGRA)
  • purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. / Yee, Jo Ann L.; Prongay, Kamm; Miles, Brodie; Smedley, Jeremy; Hansen, Scott G.; Axthelm, Michael K.; Ardeshir, Amir; Van Rompay, Koen K.A.; Timmel, Gregory; Roberts, Jeffrey A.

In: Journal of medical primatology, Vol. 48, No. 4, 01.08.2019, p. 260-263.

Research output: Contribution to journalArticle

Yee, JAL, Prongay, K, Miles, B, Smedley, J, Hansen, SG, Axthelm, MK, Ardeshir, A, Van Rompay, KKA, Timmel, G & Roberts, JA 2019, 'Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates', Journal of medical primatology, vol. 48, no. 4, pp. 260-263. https://doi.org/10.1111/jmp.12420
Yee, Jo Ann L. ; Prongay, Kamm ; Miles, Brodie ; Smedley, Jeremy ; Hansen, Scott G. ; Axthelm, Michael K. ; Ardeshir, Amir ; Van Rompay, Koen K.A. ; Timmel, Gregory ; Roberts, Jeffrey A. / Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. In: Journal of medical primatology. 2019 ; Vol. 48, No. 4. pp. 260-263.
@article{5ab7dd0128d142b1a75290643364458b,
title = "Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates",
abstract = "We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.",
keywords = "cell-mediated immune response (CMI), interferon-gamma release assay (IGRA), purified protein derivative—tuberculin (PPD)",
author = "Yee, {Jo Ann L.} and Kamm Prongay and Brodie Miles and Jeremy Smedley and Hansen, {Scott G.} and Axthelm, {Michael K.} and Amir Ardeshir and {Van Rompay}, {Koen K.A.} and Gregory Timmel and Roberts, {Jeffrey A}",
year = "2019",
month = "8",
day = "1",
doi = "10.1111/jmp.12420",
language = "English (US)",
volume = "48",
pages = "260--263",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

AU - Yee, Jo Ann L.

AU - Prongay, Kamm

AU - Miles, Brodie

AU - Smedley, Jeremy

AU - Hansen, Scott G.

AU - Axthelm, Michael K.

AU - Ardeshir, Amir

AU - Van Rompay, Koen K.A.

AU - Timmel, Gregory

AU - Roberts, Jeffrey A

PY - 2019/8/1

Y1 - 2019/8/1

N2 - We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

AB - We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

KW - cell-mediated immune response (CMI)

KW - interferon-gamma release assay (IGRA)

KW - purified protein derivative—tuberculin (PPD)

UR - http://www.scopus.com/inward/record.url?scp=85065310036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065310036&partnerID=8YFLogxK

U2 - 10.1111/jmp.12420

DO - 10.1111/jmp.12420

M3 - Article

VL - 48

SP - 260

EP - 263

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

SN - 0047-2565

IS - 4

ER -