Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott G. Hansen, Michael K. Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A Roberts

Research output: Contribution to journalArticle

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalJournal of medical primatology
Volume48
Issue number4
DOIs
StatePublished - Aug 1 2019

Keywords

  • cell-mediated immune response (CMI)
  • interferon-gamma release assay (IGRA)
  • purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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  • Cite this

    Yee, J. A. L., Prongay, K., Miles, B., Smedley, J., Hansen, S. G., Axthelm, M. K., Ardeshir, A., Van Rompay, K. K. A., Timmel, G., & Roberts, J. A. (2019). Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. Journal of medical primatology, 48(4), 260-263. https://doi.org/10.1111/jmp.12420