Interferon-gamma inhibits healing post scald burn injury

Haitao Shen, Pamela Yao, Eunyoung Lee, David G Greenhalgh, Athena Soulika

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Impaired healing after severe burns remains a reason for prolonged hospitalization, opportunistic infections, and debilitating scarring. Interferon-gamma (IFN-γ) is an important immune regulator that has been shown to inhibit collagen synthesis by fibroblasts, resulting in delayed healing in incision wounds. To determine whether IFN-γ plays similar roles in the healing process after severe burn, we induced scald injury in mice deficient or sufficient in IFN-γ and examined local responses. In the absence of IFN-γ, scalded areas healed faster. This was associated with attenuated local inflammatory responses, enhanced reepithelialization, increased proliferation of keratinocytes in reepithelialized leading edges, and up-regulation of growth factors in burned skin areas. Furthermore, angiogenesis and myofibroblast formation commenced and terminated earlier in IFN-γ-/- mice compared with wild type (WT) controls. Our observations demonstrate that inhibition of IFN-γ results in accelerated healing after burn injury by dampening excessive inflammation and facilitating reepithelialization, collagen deposition, and wound contraction.

Original languageEnglish (US)
Pages (from-to)580-591
Number of pages12
JournalWound Repair and Regeneration
Volume20
Issue number4
DOIs
StatePublished - Jul 2012

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ASJC Scopus subject areas

  • Dermatology
  • Surgery

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