Interferon alters intracellular transport of vesicular stomatitis virus glycoprotein

V. K. Singh, R. K. Maheshwari, G. P. Damewood IV, C. B. Stephensen, C. Oliver, R. M. Friedman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Double-label immunofluorescence staining studies in virus-infected subclone 11 of L(B) cells indiated that almost all of the vesicular stomatitis virus (VSV) glycoprotein (G) was plasma membrane-associated during the logarithmic phase of virus replication. In contrast, treatment with interferon (IFN) resulted in inhibition of VSV-G transport, so that almost all of the G remained associated with the Golgi complex (GC) at comparable times after infection. In both IFN-treated and control cells, G was resistant to treatment with the enzyme endo-β-N-acetylglucosamine H (endo H) indicating that the bulk of the G had reached the trans compartment of the GC.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalJournal of Biological Regulators and Homeostatic Agents
Volume2
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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