Interferon-γ: A key immunoregulatory lymphokine

John G. Williams, Gregory Jurkovich, Ronald V. Maier

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Interferon-γ is an important component of numerous host responses to inflammatory insults. Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications. In addition to reviewing our current understanding of the in vitro and in vivo actions of interferon-γ, this article cautions that the potential for adverse reactions exists when interferon-γ is administered to an immunologically competent host.

Original languageEnglish (US)
Pages (from-to)79-93
Number of pages15
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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