Abstract
Interferon-γ is an important component of numerous host responses to inflammatory insults. Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications. In addition to reviewing our current understanding of the in vitro and in vivo actions of interferon-γ, this article cautions that the potential for adverse reactions exists when interferon-γ is administered to an immunologically competent host.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 79-93 |
| Number of pages | 15 |
| Journal | Journal of Surgical Research |
| Volume | 54 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Interferon-γ : A key immunoregulatory lymphokine. / Williams, John G.; Jurkovich, Gregory; Maier, Ronald V.
In: Journal of Surgical Research, Vol. 54, No. 1, 01.01.1993, p. 79-93.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Interferon-γ
T2 - A key immunoregulatory lymphokine
AU - Williams, John G.
AU - Jurkovich, Gregory
AU - Maier, Ronald V.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Interferon-γ is an important component of numerous host responses to inflammatory insults. Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications. In addition to reviewing our current understanding of the in vitro and in vivo actions of interferon-γ, this article cautions that the potential for adverse reactions exists when interferon-γ is administered to an immunologically competent host.
AB - Interferon-γ is an important component of numerous host responses to inflammatory insults. Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications. In addition to reviewing our current understanding of the in vitro and in vivo actions of interferon-γ, this article cautions that the potential for adverse reactions exists when interferon-γ is administered to an immunologically competent host.
UR - http://www.scopus.com/inward/record.url?scp=0027447381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027447381&partnerID=8YFLogxK
U2 - 10.1006/jsre.1993.1013
DO - 10.1006/jsre.1993.1013
M3 - Review article
C2 - 8429643
AN - SCOPUS:0027447381
VL - 54
SP - 79
EP - 93
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 1
ER -