Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid

Thomas F. O'Brien, Maria Del Pilar Pla, Kenneth H. Mayer, Hiroichi Kishi, Elaine Gilleece, Michael Syvanen, John D. Hopkins

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Bacteria of different genera isolated at nine medical centers in different parts of the United States and at one center in Venezuela during the first decade of gentamicin usage carried the gentamicin resistance gene 2″-aminoglycoside nucleotidyltransferase on the same transferable plasmid. Such widespread dissemination of a newly observed resistance gene on one plasmid suggests that a new resistance gene may emerge once on a single plasmid, which then carries it to other centers and other plasmids. The resistance gene might, therefore, be contained if detected early.

Original languageEnglish (US)
Pages (from-to)87-88
Number of pages2
JournalScience
Volume230
Issue number4721
StatePublished - 1985
Externally publishedYes

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Microbial Drug Resistance
Plasmids
Gentamicins
Genes
Nucleotidyltransferases
Venezuela
Aminoglycosides
Bacteria

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

O'Brien, T. F., Pla, M. D. P., Mayer, K. H., Kishi, H., Gilleece, E., Syvanen, M., & Hopkins, J. D. (1985). Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid. Science, 230(4721), 87-88.

Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid. / O'Brien, Thomas F.; Pla, Maria Del Pilar; Mayer, Kenneth H.; Kishi, Hiroichi; Gilleece, Elaine; Syvanen, Michael; Hopkins, John D.

In: Science, Vol. 230, No. 4721, 1985, p. 87-88.

Research output: Contribution to journalArticle

O'Brien, TF, Pla, MDP, Mayer, KH, Kishi, H, Gilleece, E, Syvanen, M & Hopkins, JD 1985, 'Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid', Science, vol. 230, no. 4721, pp. 87-88.
O'Brien TF, Pla MDP, Mayer KH, Kishi H, Gilleece E, Syvanen M et al. Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid. Science. 1985;230(4721):87-88.
O'Brien, Thomas F. ; Pla, Maria Del Pilar ; Mayer, Kenneth H. ; Kishi, Hiroichi ; Gilleece, Elaine ; Syvanen, Michael ; Hopkins, John D. / Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid. In: Science. 1985 ; Vol. 230, No. 4721. pp. 87-88.
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