Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid

Thomas F. O'Brien, Maria Del Pilar Pla, Kenneth H. Mayer, Hiroichi Kishi, Elaine Gilleece, Michael Syvanen, John D. Hopkins

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Bacteria of different genera isolated at nine medical centers in different parts of the United States and at one center in Venezuela during the first decade of gentamicin usage carried the gentamicin resistance gene 2″-aminoglycoside nucleotidyltransferase on the same transferable plasmid. Such widespread dissemination of a newly observed resistance gene on one plasmid suggests that a new resistance gene may emerge once on a single plasmid, which then carries it to other centers and other plasmids. The resistance gene might, therefore, be contained if detected early.

Original languageEnglish (US)
Pages (from-to)87-88
Number of pages2
Issue number4721
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • General


Dive into the research topics of 'Intercontinental spread of a new antibiotic resistance gene on an epidemic plasmid'. Together they form a unique fingerprint.

Cite this