Abstract
Introduction: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. Methods: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. Results: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were. APOE ε4 positive. Discussion: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were. APOE ε4 positive.
Original language | English (US) |
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Journal | Alzheimer's and Dementia |
DOIs | |
State | Accepted/In press - 2015 |
Keywords
- ABI
- Alzheimer's disease
- Ankle-brachial index
- Atherosclerosis
- Blood pressure
- Cerebrovascular disease
- Dementia
- Framingham Heart Study
- Interarm differences in systolic blood pressure
- Magnetic resonance imaging
- Peripheral vascular disease
ASJC Scopus subject areas
- Clinical Neurology
- Developmental Neuroscience
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Epidemiology
- Health Policy