Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury

Matthew P. Pase; Alexa Beiser; Hugo Aparicio; Charles DeCarli; Ramachandran S. Vasan; Joanne Murabito; Sudha Seshadri

doi:10.1016/j.jalz.2015.09.006

Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury

Matthew P. Pase, Alexa Beiser, Hugo Aparicio, Charles DeCarli, Ramachandran S. Vasan, Joanne Murabito, Sudha Seshadri

Neurology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. Methods: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. Results: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were. APOE ε4 positive. Discussion: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were. APOE ε4 positive.

Original language	English (US)
Journal	Alzheimer's and Dementia
DOIs	https://doi.org/10.1016/j.jalz.2015.09.006
State	Accepted/In press - 2015

Keywords

ABI
Alzheimer's disease
Ankle-brachial index
Atherosclerosis
Blood pressure
Cerebrovascular disease
Dementia
Framingham Heart Study
Interarm differences in systolic blood pressure
Magnetic resonance imaging
Peripheral vascular disease

ASJC Scopus subject areas

Clinical Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Geriatrics and Gerontology
Epidemiology
Health Policy

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@article{25a180884eb84b3da02e8dbbd9370d37,

title = "Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury",

abstract = "Introduction: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. Methods: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. Results: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were. APOE ε4 positive. Discussion: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were. APOE ε4 positive.",

keywords = "ABI, Alzheimer's disease, Ankle-brachial index, Atherosclerosis, Blood pressure, Cerebrovascular disease, Dementia, Framingham Heart Study, Interarm differences in systolic blood pressure, Magnetic resonance imaging, Peripheral vascular disease",

author = "Pase, {Matthew P.} and Alexa Beiser and Hugo Aparicio and Charles DeCarli and Vasan, {Ramachandran S.} and Joanne Murabito and Sudha Seshadri",

year = "2015",

doi = "10.1016/j.jalz.2015.09.006",

language = "English (US)",

journal = "Alzheimer's and Dementia",

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T1 - Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury

AU - Pase, Matthew P.

AU - Beiser, Alexa

AU - Aparicio, Hugo

AU - DeCarli, Charles

AU - Vasan, Ramachandran S.

AU - Murabito, Joanne

AU - Seshadri, Sudha

PY - 2015

Y1 - 2015

N2 - Introduction: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. Methods: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. Results: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were. APOE ε4 positive. Discussion: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were. APOE ε4 positive.

AB - Introduction: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. Methods: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. Results: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were. APOE ε4 positive. Discussion: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were. APOE ε4 positive.

KW - ABI

KW - Alzheimer's disease

KW - Ankle-brachial index

KW - Atherosclerosis

KW - Blood pressure

KW - Cerebrovascular disease

KW - Dementia

KW - Framingham Heart Study

KW - Interarm differences in systolic blood pressure

KW - Magnetic resonance imaging

KW - Peripheral vascular disease

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