Interactive effects of age and hypertension on volumes of brain structures

Terri L. Strassburger, Hing Chung Lee, Eileen M. Daly, Joanna Szczepanik, Jack S. Krasuski, Marc J. Mentis, Judith A. Salerno, Charles DeCarli, Mark B. Schapiro, Gene E. Alexander

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Background and Purpose: Advanced age and hypertension have each been associated with changes in brain morphology and cognitive function. To investigate the interaction of age and hypertension with structural brain changes and neuropsychological performance in otherwise healthy patients with essential hypertension, we compared young-old (ages 56 to 69 years) and old- old (ages 70 to 84 years) hypertensive patients (n=27) with 20 age-matched normotensive healthy control subjects, using quantitative volumetric MRI and a battery of neuropsychological tests. Methods: Quantitative regions of interest and segmentation analyses were applied to MRI scans of brain to measure volumes of different brain structures and of cerebrospinal fluid (CSF). Severity of white matter hyperintensities (WMHs) was qualitatively rated in the MRI scans. A battery of neuropsychological tests was administered to each subject. Results: The combined hypertensive group (young-old and old-old) had smaller volumes of thalamic nuclei and larger volumes of CSF in the cerebellum and temporal lobes and showed poorer performance in memory and language tests than did the control subjects. Main effects for age were significant in multiple brain regions of interest. The old-old hypertensive patients and age-matched control subjects demonstrated volume reductions in brain structures and increases in ventricular and peripheral CSF volumes compared with the younger subjects. There was a significant group x age-group interaction in temporal and occipital CSF, not related to WMH, with the old-old hypertensive patients having significantly larger CSF volumes in these regions than the young-old hypertensives and both healthy control groups. Conclusions: Hypertension exacerbates the morphological changes accompanying advanced age. Temporal and occipital regions appear most vulnerable to brain atrophy due to the interactive effects of age and hypertension.

Original languageEnglish (US)
Pages (from-to)1410-1417
Number of pages8
JournalStroke
Volume28
Issue number7
StatePublished - Jul 1997
Externally publishedYes

Fingerprint

Hypertension
Cerebrospinal Fluid
Brain
Neuropsychological Tests
Temporal Lobe
Magnetic Resonance Imaging
Language Tests
Occipital Lobe
Thalamic Nuclei
Cerebellum
Cognition
Atrophy
Healthy Volunteers
Age Groups
Control Groups
White Matter

Keywords

  • Aging
  • Hypertension
  • Magnetic resonance imaging
  • Neuropsychology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Strassburger, T. L., Lee, H. C., Daly, E. M., Szczepanik, J., Krasuski, J. S., Mentis, M. J., ... Alexander, G. E. (1997). Interactive effects of age and hypertension on volumes of brain structures. Stroke, 28(7), 1410-1417.

Interactive effects of age and hypertension on volumes of brain structures. / Strassburger, Terri L.; Lee, Hing Chung; Daly, Eileen M.; Szczepanik, Joanna; Krasuski, Jack S.; Mentis, Marc J.; Salerno, Judith A.; DeCarli, Charles; Schapiro, Mark B.; Alexander, Gene E.

In: Stroke, Vol. 28, No. 7, 07.1997, p. 1410-1417.

Research output: Contribution to journalArticle

Strassburger, TL, Lee, HC, Daly, EM, Szczepanik, J, Krasuski, JS, Mentis, MJ, Salerno, JA, DeCarli, C, Schapiro, MB & Alexander, GE 1997, 'Interactive effects of age and hypertension on volumes of brain structures', Stroke, vol. 28, no. 7, pp. 1410-1417.
Strassburger TL, Lee HC, Daly EM, Szczepanik J, Krasuski JS, Mentis MJ et al. Interactive effects of age and hypertension on volumes of brain structures. Stroke. 1997 Jul;28(7):1410-1417.
Strassburger, Terri L. ; Lee, Hing Chung ; Daly, Eileen M. ; Szczepanik, Joanna ; Krasuski, Jack S. ; Mentis, Marc J. ; Salerno, Judith A. ; DeCarli, Charles ; Schapiro, Mark B. ; Alexander, Gene E. / Interactive effects of age and hypertension on volumes of brain structures. In: Stroke. 1997 ; Vol. 28, No. 7. pp. 1410-1417.
@article{1d286575000945d79a430f38a9d9ec7f,
title = "Interactive effects of age and hypertension on volumes of brain structures",
abstract = "Background and Purpose: Advanced age and hypertension have each been associated with changes in brain morphology and cognitive function. To investigate the interaction of age and hypertension with structural brain changes and neuropsychological performance in otherwise healthy patients with essential hypertension, we compared young-old (ages 56 to 69 years) and old- old (ages 70 to 84 years) hypertensive patients (n=27) with 20 age-matched normotensive healthy control subjects, using quantitative volumetric MRI and a battery of neuropsychological tests. Methods: Quantitative regions of interest and segmentation analyses were applied to MRI scans of brain to measure volumes of different brain structures and of cerebrospinal fluid (CSF). Severity of white matter hyperintensities (WMHs) was qualitatively rated in the MRI scans. A battery of neuropsychological tests was administered to each subject. Results: The combined hypertensive group (young-old and old-old) had smaller volumes of thalamic nuclei and larger volumes of CSF in the cerebellum and temporal lobes and showed poorer performance in memory and language tests than did the control subjects. Main effects for age were significant in multiple brain regions of interest. The old-old hypertensive patients and age-matched control subjects demonstrated volume reductions in brain structures and increases in ventricular and peripheral CSF volumes compared with the younger subjects. There was a significant group x age-group interaction in temporal and occipital CSF, not related to WMH, with the old-old hypertensive patients having significantly larger CSF volumes in these regions than the young-old hypertensives and both healthy control groups. Conclusions: Hypertension exacerbates the morphological changes accompanying advanced age. Temporal and occipital regions appear most vulnerable to brain atrophy due to the interactive effects of age and hypertension.",
keywords = "Aging, Hypertension, Magnetic resonance imaging, Neuropsychology",
author = "Strassburger, {Terri L.} and Lee, {Hing Chung} and Daly, {Eileen M.} and Joanna Szczepanik and Krasuski, {Jack S.} and Mentis, {Marc J.} and Salerno, {Judith A.} and Charles DeCarli and Schapiro, {Mark B.} and Alexander, {Gene E.}",
year = "1997",
month = "7",
language = "English (US)",
volume = "28",
pages = "1410--1417",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Interactive effects of age and hypertension on volumes of brain structures

AU - Strassburger, Terri L.

AU - Lee, Hing Chung

AU - Daly, Eileen M.

AU - Szczepanik, Joanna

AU - Krasuski, Jack S.

AU - Mentis, Marc J.

AU - Salerno, Judith A.

AU - DeCarli, Charles

AU - Schapiro, Mark B.

AU - Alexander, Gene E.

PY - 1997/7

Y1 - 1997/7

N2 - Background and Purpose: Advanced age and hypertension have each been associated with changes in brain morphology and cognitive function. To investigate the interaction of age and hypertension with structural brain changes and neuropsychological performance in otherwise healthy patients with essential hypertension, we compared young-old (ages 56 to 69 years) and old- old (ages 70 to 84 years) hypertensive patients (n=27) with 20 age-matched normotensive healthy control subjects, using quantitative volumetric MRI and a battery of neuropsychological tests. Methods: Quantitative regions of interest and segmentation analyses were applied to MRI scans of brain to measure volumes of different brain structures and of cerebrospinal fluid (CSF). Severity of white matter hyperintensities (WMHs) was qualitatively rated in the MRI scans. A battery of neuropsychological tests was administered to each subject. Results: The combined hypertensive group (young-old and old-old) had smaller volumes of thalamic nuclei and larger volumes of CSF in the cerebellum and temporal lobes and showed poorer performance in memory and language tests than did the control subjects. Main effects for age were significant in multiple brain regions of interest. The old-old hypertensive patients and age-matched control subjects demonstrated volume reductions in brain structures and increases in ventricular and peripheral CSF volumes compared with the younger subjects. There was a significant group x age-group interaction in temporal and occipital CSF, not related to WMH, with the old-old hypertensive patients having significantly larger CSF volumes in these regions than the young-old hypertensives and both healthy control groups. Conclusions: Hypertension exacerbates the morphological changes accompanying advanced age. Temporal and occipital regions appear most vulnerable to brain atrophy due to the interactive effects of age and hypertension.

AB - Background and Purpose: Advanced age and hypertension have each been associated with changes in brain morphology and cognitive function. To investigate the interaction of age and hypertension with structural brain changes and neuropsychological performance in otherwise healthy patients with essential hypertension, we compared young-old (ages 56 to 69 years) and old- old (ages 70 to 84 years) hypertensive patients (n=27) with 20 age-matched normotensive healthy control subjects, using quantitative volumetric MRI and a battery of neuropsychological tests. Methods: Quantitative regions of interest and segmentation analyses were applied to MRI scans of brain to measure volumes of different brain structures and of cerebrospinal fluid (CSF). Severity of white matter hyperintensities (WMHs) was qualitatively rated in the MRI scans. A battery of neuropsychological tests was administered to each subject. Results: The combined hypertensive group (young-old and old-old) had smaller volumes of thalamic nuclei and larger volumes of CSF in the cerebellum and temporal lobes and showed poorer performance in memory and language tests than did the control subjects. Main effects for age were significant in multiple brain regions of interest. The old-old hypertensive patients and age-matched control subjects demonstrated volume reductions in brain structures and increases in ventricular and peripheral CSF volumes compared with the younger subjects. There was a significant group x age-group interaction in temporal and occipital CSF, not related to WMH, with the old-old hypertensive patients having significantly larger CSF volumes in these regions than the young-old hypertensives and both healthy control groups. Conclusions: Hypertension exacerbates the morphological changes accompanying advanced age. Temporal and occipital regions appear most vulnerable to brain atrophy due to the interactive effects of age and hypertension.

KW - Aging

KW - Hypertension

KW - Magnetic resonance imaging

KW - Neuropsychology

UR - http://www.scopus.com/inward/record.url?scp=17144444814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144444814&partnerID=8YFLogxK

M3 - Article

C2 - 9227693

AN - SCOPUS:17144444814

VL - 28

SP - 1410

EP - 1417

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 7

ER -