Abstract
Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-729 |
| Number of pages | 5 |
| Journal | Experimental Neurology |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats. / Albertson, Timothy E; Foulke, G. E.
In: Experimental Neurology, Vol. 97, No. 3, 1987, p. 725-729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats
AU - Albertson, Timothy E
AU - Foulke, G. E.
PY - 1987
Y1 - 1987
N2 - Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.
AB - Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023201231&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(87)90128-2
DO - 10.1016/0014-4886(87)90128-2
M3 - Article
C2 - 2887453
AN - SCOPUS:0023201231
VL - 97
SP - 725
EP - 729
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 3
ER -