Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats

Timothy E Albertson; G. E. Foulke

doi:10.1016/0014-4886(87)90128-2

Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats

Timothy E Albertson, G. E. Foulke

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.

Original language	English (US)
Pages (from-to)	725-729
Number of pages	5
Journal	Experimental Neurology
Volume	97
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(87)90128-2
State	Published - 1987

ASJC Scopus subject areas

Neuroscience(all)
Neurology

Access to Document

10.1016/0014-4886(87)90128-2

Cite this

@article{7f7b566686a74689944505c25595ecef,

title = "Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats",

abstract = "Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.",

author = "Albertson, {Timothy E} and Foulke, {G. E.}",

year = "1987",

doi = "10.1016/0014-4886(87)90128-2",

language = "English (US)",

volume = "97",

pages = "725--729",

journal = "Neurodegeneration",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats

AU - Albertson, Timothy E

AU - Foulke, G. E.

PY - 1987

Y1 - 1987

N2 - Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.

AB - Fully amygdala-kindled rats were used to study the effect of diazepam, RO 15-1788, and CGS-8216 on aminophylline-induced prolongation of elicited kindled afterdischarges. Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline. The partial agonist effect of the benzodiazepine antagonist RO 15-1788 was demonstrated before and after aminophylline pretreatment. However, no specific interaction (pro- or anticonvulsant) was demonstrated with the benzodiazepine antagonist CGS-8216 before or after aminophylline pretreatment. Together these data do not support the theory that the prolongation of elicited kindled seizures by the methylxanthine, aminophylline, is through a specific benzodiazepine receptor mechanism.

UR - http://www.scopus.com/inward/record.url?scp=0023201231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023201231&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(87)90128-2

DO - 10.1016/0014-4886(87)90128-2

M3 - Article

C2 - 2887453

AN - SCOPUS:0023201231

VL - 97

SP - 725

EP - 729

JO - Neurodegeneration

JF - Neurodegeneration

SN - 0014-4886

IS - 3

ER -

Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this