Abstract
The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-93 |
| Number of pages | 9 |
| Journal | Nature |
| Volume | 535 |
| Issue number | 7610 |
| DOIs | |
| State | Published - Jul 6 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- General
Cite this
Interactions between the microbiota and pathogenic bacteria in the gut. / Baumler, Andreas J; Sperandio, Vanessa.
In: Nature, Vol. 535, No. 7610, 06.07.2016, p. 85-93.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Interactions between the microbiota and pathogenic bacteria in the gut
AU - Baumler, Andreas J
AU - Sperandio, Vanessa
PY - 2016/7/6
Y1 - 2016/7/6
N2 - The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.
AB - The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=84977620054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84977620054&partnerID=8YFLogxK
U2 - 10.1038/nature18849
DO - 10.1038/nature18849
M3 - Review article
C2 - 27383983
AN - SCOPUS:84977620054
VL - 535
SP - 85
EP - 93
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7610
ER -