Interaction of vagal lung afferent with inhalation of histamine aerosol in anesthetized dogs

Edward S Schelegle, J. K. Mansoor, J. F. Green

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In seven alpha-chloralose anesthetized dogs we examined the contribution of lung afferent to the rapid, shallow breathing induced by inhalation of 10 breaths of histamine aerosol. In four spontaneously breathing dogs, the inhalation of histamine caused an increased respiratory frequency, decreased tidal volume, and decreased dynamic lung compliance. Selective blockade of pulmonary C-fibers abolished a reflex-induced increase in respiratory frequency, but did not significantly affect the reductions in tidal volume or lung compliance. Terbutaline treatment in combination with C-fiber blockade abolished the reductions in tidal volume and lung compliance induced by histamine. In three separate alpha-chloralose anesthetized, open-chest, mechanically ventilated dogs, we recorded an increase in the inspiratory activity of rapidly adapting pulmonary stretch receptors (RARs) induced by the inhalation of histamine aerosol. Selective C-fiber blockade abolished histamine-induced increases in RAR activity while only partially attenuating reductions in lung compliance. We conclude that the increase in RAR activity induced by histamine depends on intact C-fibers and not on a direct effect of histamine on RARs or an indirect effect of histamine reducing lung compliance. In addition, our data illustrate the multiple interactions that occur between the various vagal afferents and their roles in the reflexes induced by histamine inhalation.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalLung
Volume178
Issue number1
StatePublished - 2000

Fingerprint

Aerosols
Histamine
Inhalation
Lung Compliance
Dogs
Pulmonary Stretch Receptors
Lung
Unmyelinated Nerve Fibers
Tidal Volume
Chloralose
Reflex
Respiration
Terbutaline
Thorax

Keywords

  • C-fibers
  • Capsaicin
  • Histamine
  • Pulmonary defense reflex
  • Rapidly adapting pulmonary stretch receptors

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Interaction of vagal lung afferent with inhalation of histamine aerosol in anesthetized dogs. / Schelegle, Edward S; Mansoor, J. K.; Green, J. F.

In: Lung, Vol. 178, No. 1, 2000, p. 41-52.

Research output: Contribution to journalArticle

Schelegle, Edward S ; Mansoor, J. K. ; Green, J. F. / Interaction of vagal lung afferent with inhalation of histamine aerosol in anesthetized dogs. In: Lung. 2000 ; Vol. 178, No. 1. pp. 41-52.
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