Interaction of gentamycin and atracurium in anaesthetised horses

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Evoked hind limb digital extensor tension (hoof twitch) was maintained at 40% of baseline for 1 h by atracurium infusion in 7 horses anaesthetised with halothane. After 1 h, atracurium was discontinued and hoof twitch allowed to recover to 75%. Atracurium was again given by infusion to maintain 40% twitch for a second hour, then 2 mg gentamycin/kg bwt were given i.v. Atracurium infusion was continued for a third hour, and then hoof twitch was again allowed to recover spontaneously to 75%. Gentamycin reduced twitch strength from 40 ± 1% (mean ± sem) to 29 ± 4% within 7.0 ± 1.5 min (P = 0.02). Twitch gradually returned to pre‐gentamycin strength over the course of the next hour. Recovery of hoof twitch from 50% to 75% took 7.7 ± 0.7 min for atracurium alone and 11.5 ± 2.7 min for atracurium plus gentamycin (P = 0.03). Recovery from 50% twitch to 75% fade recovery took 13.8 ± 0.8 min for atracurium alone and 13.7 ± 1.2 min for atracurium plus gentamycin. At 75% recovery of fade, hoof twitch was 87 ± 3% for atracurium alone and 82 ± 4% for atracurium plus gentamycin. Reversal of the block with edrophonium and subsequent recovery of the horses from anaesthesia were uneventful. It was concluded that, although gentamycin did augment the neuromuscular blockade of atracurium, the effect was minimal.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalEquine Veterinary Journal
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Atracurium
gentamicin
Gentamicins
hooves
Horses
horses
Hoof and Claw
halothane
anesthesia
Edrophonium
Neuromuscular Blockade
Halothane
Extremities
Anesthesia

Keywords

  • anaesthesia
  • antibiotics
  • horse
  • muscle relaxants

ASJC Scopus subject areas

  • Medicine(all)
  • Equine

Cite this

Interaction of gentamycin and atracurium in anaesthetised horses. / Hildebrand, Susan; HILL, T.

In: Equine Veterinary Journal, Vol. 26, No. 3, 01.01.1994, p. 209-211.

Research output: Contribution to journalArticle

@article{fefa0115a54742ce82af3a98d85a9eaa,
title = "Interaction of gentamycin and atracurium in anaesthetised horses",
abstract = "Evoked hind limb digital extensor tension (hoof twitch) was maintained at 40{\%} of baseline for 1 h by atracurium infusion in 7 horses anaesthetised with halothane. After 1 h, atracurium was discontinued and hoof twitch allowed to recover to 75{\%}. Atracurium was again given by infusion to maintain 40{\%} twitch for a second hour, then 2 mg gentamycin/kg bwt were given i.v. Atracurium infusion was continued for a third hour, and then hoof twitch was again allowed to recover spontaneously to 75{\%}. Gentamycin reduced twitch strength from 40 ± 1{\%} (mean ± sem) to 29 ± 4{\%} within 7.0 ± 1.5 min (P = 0.02). Twitch gradually returned to pre‐gentamycin strength over the course of the next hour. Recovery of hoof twitch from 50{\%} to 75{\%} took 7.7 ± 0.7 min for atracurium alone and 11.5 ± 2.7 min for atracurium plus gentamycin (P = 0.03). Recovery from 50{\%} twitch to 75{\%} fade recovery took 13.8 ± 0.8 min for atracurium alone and 13.7 ± 1.2 min for atracurium plus gentamycin. At 75{\%} recovery of fade, hoof twitch was 87 ± 3{\%} for atracurium alone and 82 ± 4{\%} for atracurium plus gentamycin. Reversal of the block with edrophonium and subsequent recovery of the horses from anaesthesia were uneventful. It was concluded that, although gentamycin did augment the neuromuscular blockade of atracurium, the effect was minimal.",
keywords = "anaesthesia, antibiotics, horse, muscle relaxants",
author = "Susan Hildebrand and T. HILL",
year = "1994",
month = "1",
day = "1",
doi = "10.1111/j.2042-3306.1994.tb04371.x",
language = "English (US)",
volume = "26",
pages = "209--211",
journal = "Equine veterinary journal. Supplement",
issn = "2042-3306",
publisher = "British Equine Veterinary Association",
number = "3",

}

TY - JOUR

T1 - Interaction of gentamycin and atracurium in anaesthetised horses

AU - Hildebrand, Susan

AU - HILL, T.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Evoked hind limb digital extensor tension (hoof twitch) was maintained at 40% of baseline for 1 h by atracurium infusion in 7 horses anaesthetised with halothane. After 1 h, atracurium was discontinued and hoof twitch allowed to recover to 75%. Atracurium was again given by infusion to maintain 40% twitch for a second hour, then 2 mg gentamycin/kg bwt were given i.v. Atracurium infusion was continued for a third hour, and then hoof twitch was again allowed to recover spontaneously to 75%. Gentamycin reduced twitch strength from 40 ± 1% (mean ± sem) to 29 ± 4% within 7.0 ± 1.5 min (P = 0.02). Twitch gradually returned to pre‐gentamycin strength over the course of the next hour. Recovery of hoof twitch from 50% to 75% took 7.7 ± 0.7 min for atracurium alone and 11.5 ± 2.7 min for atracurium plus gentamycin (P = 0.03). Recovery from 50% twitch to 75% fade recovery took 13.8 ± 0.8 min for atracurium alone and 13.7 ± 1.2 min for atracurium plus gentamycin. At 75% recovery of fade, hoof twitch was 87 ± 3% for atracurium alone and 82 ± 4% for atracurium plus gentamycin. Reversal of the block with edrophonium and subsequent recovery of the horses from anaesthesia were uneventful. It was concluded that, although gentamycin did augment the neuromuscular blockade of atracurium, the effect was minimal.

AB - Evoked hind limb digital extensor tension (hoof twitch) was maintained at 40% of baseline for 1 h by atracurium infusion in 7 horses anaesthetised with halothane. After 1 h, atracurium was discontinued and hoof twitch allowed to recover to 75%. Atracurium was again given by infusion to maintain 40% twitch for a second hour, then 2 mg gentamycin/kg bwt were given i.v. Atracurium infusion was continued for a third hour, and then hoof twitch was again allowed to recover spontaneously to 75%. Gentamycin reduced twitch strength from 40 ± 1% (mean ± sem) to 29 ± 4% within 7.0 ± 1.5 min (P = 0.02). Twitch gradually returned to pre‐gentamycin strength over the course of the next hour. Recovery of hoof twitch from 50% to 75% took 7.7 ± 0.7 min for atracurium alone and 11.5 ± 2.7 min for atracurium plus gentamycin (P = 0.03). Recovery from 50% twitch to 75% fade recovery took 13.8 ± 0.8 min for atracurium alone and 13.7 ± 1.2 min for atracurium plus gentamycin. At 75% recovery of fade, hoof twitch was 87 ± 3% for atracurium alone and 82 ± 4% for atracurium plus gentamycin. Reversal of the block with edrophonium and subsequent recovery of the horses from anaesthesia were uneventful. It was concluded that, although gentamycin did augment the neuromuscular blockade of atracurium, the effect was minimal.

KW - anaesthesia

KW - antibiotics

KW - horse

KW - muscle relaxants

UR - http://www.scopus.com/inward/record.url?scp=0028439852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028439852&partnerID=8YFLogxK

U2 - 10.1111/j.2042-3306.1994.tb04371.x

DO - 10.1111/j.2042-3306.1994.tb04371.x

M3 - Article

C2 - 8542840

AN - SCOPUS:0028439852

VL - 26

SP - 209

EP - 211

JO - Equine veterinary journal. Supplement

JF - Equine veterinary journal. Supplement

SN - 2042-3306

IS - 3

ER -