Interaction of epithelium with mesenchyme affects global features of lung architecture: A computer model of development

Seth Tebockhorst, DongYoub Lee, Anthony S. Wexler, Michael J. Oldham

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Lung airway morphogenesis is simulated in a simplified diffusing environment that simulates the mesenchyme to explore the role of morphogens in airway architecture development. Simple rules govern local branching morphogenesis. Morphogen gradients are modeled by four pairs of sources and their diffusion through the mesenchyme. Sensitivity to lobar architecture and mesenchymal morphogen are explored. Even if the model accurately represents observed patterns of local development, it could not produce realistic global patterns of lung architecture if interaction with its environment was not taken into account, implying that reciprocal interaction between airway growth and morphogens in the mesenchyme plays a critical role in producing realistic global features of lung architecture.

Original languageEnglish (US)
Pages (from-to)294-305
Number of pages12
JournalJournal of Applied Physiology
Volume102
Issue number1
DOIs
StatePublished - Jan 2007

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Keywords

  • Airway development
  • Promoter signaling

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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