Abstract
Lung airway morphogenesis is simulated in a simplified diffusing environment that simulates the mesenchyme to explore the role of morphogens in airway architecture development. Simple rules govern local branching morphogenesis. Morphogen gradients are modeled by four pairs of sources and their diffusion through the mesenchyme. Sensitivity to lobar architecture and mesenchymal morphogen are explored. Even if the model accurately represents observed patterns of local development, it could not produce realistic global patterns of lung architecture if interaction with its environment was not taken into account, implying that reciprocal interaction between airway growth and morphogens in the mesenchyme plays a critical role in producing realistic global features of lung architecture.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 294-305 |
| Number of pages | 12 |
| Journal | Journal of Applied Physiology |
| Volume | 102 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2007 |
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Keywords
- Airway development
- Promoter signaling
ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Interaction of epithelium with mesenchyme affects global features of lung architecture : A computer model of development. / Tebockhorst, Seth; Lee, DongYoub; Wexler, Anthony S.; Oldham, Michael J.
In: Journal of Applied Physiology, Vol. 102, No. 1, 01.2007, p. 294-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction of epithelium with mesenchyme affects global features of lung architecture
T2 - A computer model of development
AU - Tebockhorst, Seth
AU - Lee, DongYoub
AU - Wexler, Anthony S.
AU - Oldham, Michael J.
PY - 2007/1
Y1 - 2007/1
N2 - Lung airway morphogenesis is simulated in a simplified diffusing environment that simulates the mesenchyme to explore the role of morphogens in airway architecture development. Simple rules govern local branching morphogenesis. Morphogen gradients are modeled by four pairs of sources and their diffusion through the mesenchyme. Sensitivity to lobar architecture and mesenchymal morphogen are explored. Even if the model accurately represents observed patterns of local development, it could not produce realistic global patterns of lung architecture if interaction with its environment was not taken into account, implying that reciprocal interaction between airway growth and morphogens in the mesenchyme plays a critical role in producing realistic global features of lung architecture.
AB - Lung airway morphogenesis is simulated in a simplified diffusing environment that simulates the mesenchyme to explore the role of morphogens in airway architecture development. Simple rules govern local branching morphogenesis. Morphogen gradients are modeled by four pairs of sources and their diffusion through the mesenchyme. Sensitivity to lobar architecture and mesenchymal morphogen are explored. Even if the model accurately represents observed patterns of local development, it could not produce realistic global patterns of lung architecture if interaction with its environment was not taken into account, implying that reciprocal interaction between airway growth and morphogens in the mesenchyme plays a critical role in producing realistic global features of lung architecture.
KW - Airway development
KW - Promoter signaling
UR - http://www.scopus.com/inward/record.url?scp=33846146074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846146074&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00665.2006
DO - 10.1152/japplphysiol.00665.2006
M3 - Article
VL - 102
SP - 294
EP - 305
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -