Interaction of cadherin with the actin cytoskeleton

W. James Nelson, Frauke Drees, Soichiro Yamada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.

Original languageEnglish (US)
Title of host publicationNovartis Foundation Symposium
Pages159-168
Number of pages10
Volume269
StatePublished - 2005
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
Volume269
ISSN (Print)15282511

Fingerprint

Cadherins
Actin Cytoskeleton
Proteins
Cell Adhesion
Cell Communication
Embryonic Development
Cluster Analysis
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nelson, W. J., Drees, F., & Yamada, S. (2005). Interaction of cadherin with the actin cytoskeleton. In Novartis Foundation Symposium (Vol. 269, pp. 159-168). (Novartis Foundation Symposium; Vol. 269).

Interaction of cadherin with the actin cytoskeleton. / Nelson, W. James; Drees, Frauke; Yamada, Soichiro.

Novartis Foundation Symposium. Vol. 269 2005. p. 159-168 (Novartis Foundation Symposium; Vol. 269).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nelson, WJ, Drees, F & Yamada, S 2005, Interaction of cadherin with the actin cytoskeleton. in Novartis Foundation Symposium. vol. 269, Novartis Foundation Symposium, vol. 269, pp. 159-168.
Nelson WJ, Drees F, Yamada S. Interaction of cadherin with the actin cytoskeleton. In Novartis Foundation Symposium. Vol. 269. 2005. p. 159-168. (Novartis Foundation Symposium).
Nelson, W. James ; Drees, Frauke ; Yamada, Soichiro. / Interaction of cadherin with the actin cytoskeleton. Novartis Foundation Symposium. Vol. 269 2005. pp. 159-168 (Novartis Foundation Symposium).
@inproceedings{4d6deb83863a423188e7c120022d4b44,
title = "Interaction of cadherin with the actin cytoskeleton",
abstract = "Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.",
author = "Nelson, {W. James} and Frauke Drees and Soichiro Yamada",
year = "2005",
language = "English (US)",
isbn = "9780470011904",
volume = "269",
series = "Novartis Foundation Symposium",
pages = "159--168",
booktitle = "Novartis Foundation Symposium",

}

TY - GEN

T1 - Interaction of cadherin with the actin cytoskeleton

AU - Nelson, W. James

AU - Drees, Frauke

AU - Yamada, Soichiro

PY - 2005

Y1 - 2005

N2 - Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.

AB - Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.

UR - http://www.scopus.com/inward/record.url?scp=33644799702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644799702&partnerID=8YFLogxK

M3 - Conference contribution

SN - 9780470011904

VL - 269

T3 - Novartis Foundation Symposium

SP - 159

EP - 168

BT - Novartis Foundation Symposium

ER -