Interaction of cadherin with the actin cytoskeleton

W. James Nelson, Frauke Drees, Soichiro Yamada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.

Original languageEnglish (US)
Title of host publicationNovartis Foundation Symposium
Pages159-168
Number of pages10
Volume269
StatePublished - 2005
Externally publishedYes

Publication series

NameNovartis Foundation Symposium
Volume269
ISSN (Print)15282511

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nelson, W. J., Drees, F., & Yamada, S. (2005). Interaction of cadherin with the actin cytoskeleton. In Novartis Foundation Symposium (Vol. 269, pp. 159-168). (Novartis Foundation Symposium; Vol. 269).