Interaction of air pollution with the MET receptor tyrosine kinase gene

Heather E. Volk, Tara Kerin, Fred Lurmann, Irva Hertz-Picciotto, Rob McConnell, Daniel B. Campbell

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

BACKGROUND:: Independent studies report association of autism spectrum disorder with air pollution exposure and a functional promoter variant (rs1858830) in the MET receptor tyrosine kinase (MET) gene. Toxicological data find altered brain Met expression in mice after prenatal exposure to a model air pollutant. Our objective was to investigate whether air pollution exposure and MET rs1858830 genotype interact to alter the risk of autism spectrum disorder. METHODS:: We studied 252 cases of autism spectrum disorder and 156 typically developing controls from the Childhood Autism Risk from Genetics and the Environment Study. Air pollution exposure was assigned for local traffic-related sources and regional sources (particulate matter, nitrogen dioxide, and ozone). MET genotype was determined by direct resequencing. RESULTS:: Subjects with both MET rs1858830 CC genotype and high air pollutant exposures were at increased risk of autism spectrum disorder compared with subjects who had both the CG/GG genotypes and lower air pollutant exposures. There was evidence of multiplicative interaction between NO2 and MET CC genotype (P= 0.03). CONCLUSIONS:: MET rs1858830 CC genotype and air pollutant exposure may interact to increase the risk of autism spectrum disorder.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalEpidemiology
Volume25
Issue number1
DOIs
StatePublished - Jan 2014

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Proto-Oncogene Proteins c-met
Air Pollution
Air Pollutants
Genotype
Genes
Nitrogen Dioxide
Particulate Matter
Ozone
Autistic Disorder
Toxicology
Autism Spectrum Disorder
Brain

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Interaction of air pollution with the MET receptor tyrosine kinase gene. / Volk, Heather E.; Kerin, Tara; Lurmann, Fred; Hertz-Picciotto, Irva; McConnell, Rob; Campbell, Daniel B.

In: Epidemiology, Vol. 25, No. 1, 01.2014, p. 44-47.

Research output: Contribution to journalArticle

Volk, HE, Kerin, T, Lurmann, F, Hertz-Picciotto, I, McConnell, R & Campbell, DB 2014, 'Interaction of air pollution with the MET receptor tyrosine kinase gene', Epidemiology, vol. 25, no. 1, pp. 44-47. https://doi.org/10.1097/EDE.0000000000000030
Volk, Heather E. ; Kerin, Tara ; Lurmann, Fred ; Hertz-Picciotto, Irva ; McConnell, Rob ; Campbell, Daniel B. / Interaction of air pollution with the MET receptor tyrosine kinase gene. In: Epidemiology. 2014 ; Vol. 25, No. 1. pp. 44-47.
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