Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats

Gerhard H. Reubel, Jeanne W. George, Jeffrey E. Barlough, Joanne Higgins, Chris K. Grant, Niels C Pedersen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cats with or without chronic feline immunodeficiency virus (FIV) infection were exposed to feline herpesvirus, type 1 (FHV-1). FIV infected cats became sicker than non-FIV infected cats and required more supportive treatment. However, there were no differences in the length of their illness or in the levels and duration of FHV-1 shedding. FHV-1 infection caused a transient neutrophilia at Day 7 with a rapid return to preinfection levels. The neutrophilia coincided with a transient lymphopenia that was accompanied by a decline in both CD4+ and CD8+ T-lymphocytes. A brief decrease in the CD4+ CD8+ T-lymphocyte ratio occurred at Day 14 in both FIV infected and non-infected cats. This decrease was mainly the result of an absolute and transient increase in CD8+ T-lymphocytes. CD4+ and CD8+ T-lymphocyte numbers and CD4+ CD8+ T-lymphocyte ratios returned to baseline within 4-8 weeks in both FIV infected and non-infected cats. FIV infected cats produced less FHV-1 neutralizing antibodies during the first 3 weeks of infection than non-FIV infected animals. The IgM FHV-1 antibody response was depressed in FIV infected cats whereas the IgG antibody response was unaffected. FHV-1 infection evoked a comparable transient loss of lymphocyte blastogenic responses to concanavalin A and pokeweed mitogen in both FIV infected and non-infected cats. However, response to pokeweed mitogen took longer to return to normal in FIV infected animals. Lymphocytes from FIV infected cats had a greater and more sustained proliferative response to FHV-1 antigen than non-FIV infected cats. The ongoing IgG antibody response to FIV was not affected by FHV-1 infection.

Original languageEnglish (US)
Pages (from-to)95-119
Number of pages25
JournalVeterinary Immunology and Immunopathology
Volume35
Issue number1-2
DOIs
StatePublished - 1992

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Feline Immunodeficiency Virus
Felid herpesvirus 1
Specific Pathogen-Free Organisms
Feline immunodeficiency virus
Herpesviridae
Felidae
Virus Diseases
Cats
cats
pathogens
infection
Herpesviridae Infections
T-lymphocytes
immunosuppression
T-Lymphocytes
Antibody Formation
Pokeweed Mitogens
Phytolacca americana
Viruses
antibodies

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats. / Reubel, Gerhard H.; George, Jeanne W.; Barlough, Jeffrey E.; Higgins, Joanne; Grant, Chris K.; Pedersen, Niels C.

In: Veterinary Immunology and Immunopathology, Vol. 35, No. 1-2, 1992, p. 95-119.

Research output: Contribution to journalArticle

Reubel, Gerhard H. ; George, Jeanne W. ; Barlough, Jeffrey E. ; Higgins, Joanne ; Grant, Chris K. ; Pedersen, Niels C. / Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats. In: Veterinary Immunology and Immunopathology. 1992 ; Vol. 35, No. 1-2. pp. 95-119.
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