Interaction of a wasp ovarian protein and polydnavirus in host immune suppression

Shirley Luckhart, Bruce A. Webb

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

During parasitization of Heliothis virescens, Campoletis sonorensis deposits an egg along with venom, polydnavirus particles (CsPDV), and ovarian proteins (OPs). Oviposited eggs are not encapsulated, while washed eggs are encapsulated rapidly by H. virescens. Early protection from encapsulation is afforded by a group of 29-36 kD OP glycoforms. These glycoforms are endocytosed by host hemocytes within 30 min post-parasitization (pp) and disrupt hemocyte spreading behavior and egg encapsulation through at least 24 h pi. Purified CsPDV does not protect eggs from encapsulation early, but disrupts hemocyte spreading and egg encapsulation from 24 h through at least 5 days pi. Functional activity of CsPDV appears to be correlated with time- dependent accumulation of virus-specific proteins in parasitized insects. We propose that the fast-acting 29-36 kD OP protects Campoletis eggs from encapsulation until accumulation of CsPDV proteins which sustain immunosuppression.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalDevelopmental and Comparative Immunology
Volume20
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

Keywords

  • Campoletis sonorensis
  • Encapsulation
  • Heliothis virescens
  • Hemocytes
  • Insect immunity
  • Parasitoid
  • Polydnavirus

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

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