Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior

Jacqueline Crawley, Pal J. Marangos, Steven M. Paul, Phil Skolnick, Frederick K. Goodwin

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Inosine, 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam. The inhibition of exploratory behavior by purines occurred at doses that when given alone have no effect on exploratory behavior. 7-Methylinosine, which does not bind to the brain benzodiazepine binding site in vitro, had no effect on the diazepam-induced increase in exploratory behavior. Behavioral effects produced by various combinations of inosine and diazepam indicate that the interaction between purine and benzodiazepine is antagonistic and support the hypothesis that the naturally occurring purines function in anxiety-related behaviors that respond to benzodiazepine treatment.

Original languageEnglish (US)
Pages (from-to)725-727
Number of pages3
JournalSciences
Volume211
Issue number4483
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • General

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