Interaction between cigarette smoke and mycoplasma infection: A murine model

Richard J. Martin, Rachel B. Wexler, Brian J. Day, Ronald J. Harbeck, Kent E Pinkerton, Hong Wei Chu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cigarette smoke has a major impact on health issues worldwide. Although genetics certainly is a factor in the sensitivity to cigarette smoke, other lung environmental factors, such as infection, potentially could interact with cigarette smoke to induce inflammatory changes associated with various diseases. Four groups of BALB/c mice (smoking only; smoking + M. pneumoniae infection; mycoplasma only; saline control) were studied for eight weeks to determine the interactive outcomes of inflammation and structural changes in the smoking plus mycoplasma group. This group did have significantly higher amounts of neutrophil degranulation in the outer airway wall area (smooth muscle to alveolar attachments) ( p = 0.03) and mRNA expression of matrix metalloproteinase-9 ( p = 0.045). Although there was not a significant difference in alveolar tissue elastin between the groups, the smoking plus mycoplasma group had a level approximately 20% below the other groups. Even in this relatively short duration study, it appears that an infectious process can interact with cigarette smoke to produce a destructive type of inflammatory response (activated neutrophils and metalloproteinase-9) seen in the outer airway wall area.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume3
Issue number1
DOIs
StatePublished - 2006

Fingerprint

Mycoplasma Infections
Smoke
Tobacco Products
Mycoplasma
Smoking
Neutrophils
Elastin
Matrix Metalloproteinase 9
Metalloproteases
Infection
Smooth Muscle
Pneumonia
Inflammation
Lung
Messenger RNA

Keywords

  • Cigarette smoke
  • COPD
  • Infection
  • Mouse model
  • Mycoplasma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Interaction between cigarette smoke and mycoplasma infection : A murine model. / Martin, Richard J.; Wexler, Rachel B.; Day, Brian J.; Harbeck, Ronald J.; Pinkerton, Kent E; Chu, Hong Wei.

In: COPD: Journal of Chronic Obstructive Pulmonary Disease, Vol. 3, No. 1, 2006, p. 3-8.

Research output: Contribution to journalArticle

Martin, Richard J. ; Wexler, Rachel B. ; Day, Brian J. ; Harbeck, Ronald J. ; Pinkerton, Kent E ; Chu, Hong Wei. / Interaction between cigarette smoke and mycoplasma infection : A murine model. In: COPD: Journal of Chronic Obstructive Pulmonary Disease. 2006 ; Vol. 3, No. 1. pp. 3-8.
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