Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

Randi J Hagerman, M. Leehey, W. Heinrichs, Flora Tassone, R. Wilson, J. Hills, J. Grigsby, B. Gage, Paul J Hagerman

Research output: Contribution to journalArticle

671 Citations (Scopus)

Abstract

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalNeurology
Volume57
Issue number1
StatePublished - Jul 10 2001

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Parkinsonian Disorders
Tremor
Intellectual Disability
Atrophy
Brain
Fragile X Mental Retardation Protein
Genes
Messenger RNA
Executive Function
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. / Hagerman, Randi J; Leehey, M.; Heinrichs, W.; Tassone, Flora; Wilson, R.; Hills, J.; Grigsby, J.; Gage, B.; Hagerman, Paul J.

In: Neurology, Vol. 57, No. 1, 10.07.2001, p. 127-130.

Research output: Contribution to journalArticle

Hagerman, RJ, Leehey, M, Heinrichs, W, Tassone, F, Wilson, R, Hills, J, Grigsby, J, Gage, B & Hagerman, PJ 2001, 'Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X', Neurology, vol. 57, no. 1, pp. 127-130.
Hagerman, Randi J ; Leehey, M. ; Heinrichs, W. ; Tassone, Flora ; Wilson, R. ; Hills, J. ; Grigsby, J. ; Gage, B. ; Hagerman, Paul J. / Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. In: Neurology. 2001 ; Vol. 57, No. 1. pp. 127-130.
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