Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

Randi J Hagerman, M. Leehey, W. Heinrichs, Flora Tassone, R. Wilson, J. Hills, J. Grigsby, B. Gage, Paul J Hagerman

Research output: Contribution to journalArticlepeer-review

727 Scopus citations

Abstract

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalNeurology
Volume57
Issue number1
StatePublished - Jul 10 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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