Intensity-modulated radiotherapy increases dose to the brachial plexus compared with conventional radiotherapy for head and neck cancer

A. M. Chen, W. H. Hall, B. Q. Li, M. Guiou, C. Wright, M. Mathai, A. Dublin, J. A. Purdy

Research output: Contribution to journalArticle

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Abstract

Objective: The preferential use of intensity-modulated radiotherapy (IMRT) over conventional radiotherapy (CRT) in the treatment of head and neck cancer has raised concerns regarding dose to non-target tissue. The purpose of this study was to compare dose-volume characteristics with the brachial plexus between treatment plans generated by IMRT and CRT using several common treatment scenarios. Method: The brachial plexus was delineated on radiation treatment planning CT scans from 10 patients undergoing IMRT for locally advanced head and neck cancer using a Radiation Therapy Oncology Group-endorsed atlas. No brachial plexus constraint was used. For each patient, a conventional three-field shrinking-field plan was generated and the dose-volume histogram (DVH) for the brachial plexus was compared with that of the IMRT plan. Results: The mean irradiated volumes of the brachial plexus using the IMRT vs the CRT plan, respectively, were as follows: V50 (18±5 ml) vs (11±6 ml), p=0.01; V60 (6±4 ml) vs (3±3 ml), p50.02; V66 (3±1 ml) vs (1±1 ml), p=0.04, V70 (0±1 ml) vs (0±1 ml), p=0.68. The maximum point dose to the brachial plexus was 68.9 Gy (range 62.3- 78.7 Gy) and 66.1 Gy (range 60.2-75.6 Gy) for the IMRT and CRT plans, respectively (p=0.01). Conclusion: Dose to the brachial plexus is significantly increased among patients undergoing IMRT compared with CRT for head and neck cancer. Preliminary studies on brachial plexus-sparing IMRT are in progress.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalBritish Journal of Radiology
Volume84
Issue number997
DOIs
StatePublished - Jan 2011

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Intensity-Modulated Radiotherapy
Brachial Plexus
Head and Neck Neoplasms
Radiotherapy
Radiation Oncology
Atlases
Therapeutics
Radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Intensity-modulated radiotherapy increases dose to the brachial plexus compared with conventional radiotherapy for head and neck cancer. / Chen, A. M.; Hall, W. H.; Li, B. Q.; Guiou, M.; Wright, C.; Mathai, M.; Dublin, A.; Purdy, J. A.

In: British Journal of Radiology, Vol. 84, No. 997, 01.2011, p. 58-63.

Research output: Contribution to journalArticle

Chen, A. M. ; Hall, W. H. ; Li, B. Q. ; Guiou, M. ; Wright, C. ; Mathai, M. ; Dublin, A. ; Purdy, J. A. / Intensity-modulated radiotherapy increases dose to the brachial plexus compared with conventional radiotherapy for head and neck cancer. In: British Journal of Radiology. 2011 ; Vol. 84, No. 997. pp. 58-63.
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