Integrators of epidermal growth and differentiation: Distinct functions for β1 and β4 integrins

Elaine Fuchs, James Dowling, Julia Segre, Su Hao Lo, Qian Chu Yu

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. Substratum attachment is essential for survival, proliferation, movement, and differentiation; detachment compromises the cell's ability to perform these functions, often resulting in human disease. Interactions with the extracellular matrix are mediated through transmembrane integrin receptors that transmit signals to the cytoskeleton and to signaling molecules within the proliferating cells of the epithelium. In the past year, novel insights have emerged regarding the specific role of integrins in their attachment to extracellular matrix and in their signal transduction pathways within the epidermis.

Original languageEnglish (US)
Pages (from-to)672-682
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume7
Issue number5
DOIs
StatePublished - Oct 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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