Abstract
Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. Substratum attachment is essential for survival, proliferation, movement, and differentiation; detachment compromises the cell's ability to perform these functions, often resulting in human disease. Interactions with the extracellular matrix are mediated through transmembrane integrin receptors that transmit signals to the cytoskeleton and to signaling molecules within the proliferating cells of the epithelium. In the past year, novel insights have emerged regarding the specific role of integrins in their attachment to extracellular matrix and in their signal transduction pathways within the epidermis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 672-682 |
| Number of pages | 11 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Integrators of epidermal growth and differentiation : Distinct functions for β1 and β4 integrins. / Fuchs, Elaine; Dowling, James; Segre, Julia; Lo, Su Hao; Yu, Qian Chu.
In: Current Opinion in Genetics and Development, Vol. 7, No. 5, 10.1997, p. 672-682.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Integrators of epidermal growth and differentiation
T2 - Distinct functions for β1 and β4 integrins
AU - Fuchs, Elaine
AU - Dowling, James
AU - Segre, Julia
AU - Lo, Su Hao
AU - Yu, Qian Chu
PY - 1997/10
Y1 - 1997/10
N2 - Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. Substratum attachment is essential for survival, proliferation, movement, and differentiation; detachment compromises the cell's ability to perform these functions, often resulting in human disease. Interactions with the extracellular matrix are mediated through transmembrane integrin receptors that transmit signals to the cytoskeleton and to signaling molecules within the proliferating cells of the epithelium. In the past year, novel insights have emerged regarding the specific role of integrins in their attachment to extracellular matrix and in their signal transduction pathways within the epidermis.
AB - Mammalian epithelia are critically dependent on interactions with components in the underlying basal lamina for proper morphogenesis and function. Substratum attachment is essential for survival, proliferation, movement, and differentiation; detachment compromises the cell's ability to perform these functions, often resulting in human disease. Interactions with the extracellular matrix are mediated through transmembrane integrin receptors that transmit signals to the cytoskeleton and to signaling molecules within the proliferating cells of the epithelium. In the past year, novel insights have emerged regarding the specific role of integrins in their attachment to extracellular matrix and in their signal transduction pathways within the epidermis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030829724&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(97)80016-0
DO - 10.1016/S0959-437X(97)80016-0
M3 - Article
C2 - 9388785
AN - SCOPUS:0030829724
VL - 7
SP - 672
EP - 682
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 5
ER -