Integrated microfluidic platform for high-throughput study of electrical field directed cell migration

S. Zhao, K. Zhu, Y. Zhang, Z. Zhu, Z. Xu, Min Zhao, Tingrui Pan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

EF induced directional cell migration, also known as electrotaxis, has recently received broad attention due to its potential application in wound healing. Current electrotaxis experimental setup is cumbersome due to the external power supply and EF controlling/monitoring systems. There is also lack of parallel experimental system for high throughput electrotaxis study. In this paper, we present a microfluidic electrotaxis platform integrating all functional components on one single credit card-sized chip. Furthermore, utilizing the R-2R resistor ladder topology in digital signal processing, we develop an infinite microfluidic EF gradient generator for high throughput study of EF directed cell migration.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1494-1496
Number of pages3
ISBN (Print)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Electrotaxis
  • High-throughput
  • Microfluidics

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Zhao, S., Zhu, K., Zhang, Y., Zhu, Z., Xu, Z., Zhao, M., & Pan, T. (2014). Integrated microfluidic platform for high-throughput study of electrical field directed cell migration. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1494-1496). Chemical and Biological Microsystems Society.