Insulin like growth factors and their importance in pediatrics.

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1 Citation (Scopus)

Abstract

Insulin-like growth factors (IGF's) are mitogenic peptides bearing homology to proinsulin. IGF's are synthesized by many cell types in mammals and have been implicated as major factors controlling growth and differentiation during fetal life, infancy and childhood. Experimental evidence for these assertions is presented, using data from animal and human studies. The effects of IGF's on normal and abnormal growth processes are discussed, and specific examples are presented of disorders related to abnormal IGF production encountered in pediatric-age patients. Discussion is also included regarding the role of milk-borne IGF for the suckling. Lastly, future uses for IGF's are mentioned, with specific examples given for treating disorders, such as short stature and diabetes due to insulin resistance.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalZhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui
Volume37
Issue number1
StatePublished - Jan 1996
Externally publishedYes

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Somatomedins
Pediatrics
Growth Differentiation Factors
Proinsulin
Insulin Resistance
Mammals
Milk
Peptides
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Insulin-like growth factors (IGF's) are mitogenic peptides bearing homology to proinsulin. IGF's are synthesized by many cell types in mammals and have been implicated as major factors controlling growth and differentiation during fetal life, infancy and childhood. Experimental evidence for these assertions is presented, using data from animal and human studies. The effects of IGF's on normal and abnormal growth processes are discussed, and specific examples are presented of disorders related to abnormal IGF production encountered in pediatric-age patients. Discussion is also included regarding the role of milk-borne IGF for the suckling. Lastly, future uses for IGF's are mentioned, with specific examples given for treating disorders, such as short stature and diabetes due to insulin resistance.",
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