Abstract
Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3059-3069 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 1 2013 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
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Cite this
Fujita, M., Takada, Y. K., & Takada, Y. (2013). Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation. Journal of Biological Chemistry, 288(5), 3059-3069. https://doi.org/10.1074/jbc.M112.412536