Abstract
Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3059-3069 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 1 2013 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation. / Fujita, Masaaki; Takada, Yoko K.; Takada, Yoshikazu.
In: Journal of Biological Chemistry, Vol. 288, No. 5, 01.02.2013, p. 3059-3069.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation
AU - Fujita, Masaaki
AU - Takada, Yoko K.
AU - Takada, Yoshikazu
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
AB - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
UR - http://www.scopus.com/inward/record.url?scp=84873282225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873282225&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.412536
DO - 10.1074/jbc.M112.412536
M3 - Article
C2 - 23243309
AN - SCOPUS:84873282225
VL - 288
SP - 3059
EP - 3069
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 5
ER -