Abstract
Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
Original language | English (US) |
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Pages (from-to) | 3059-3069 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 5 |
DOIs | |
State | Published - Feb 1 2013 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology