Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

Masaaki Fujita; Yoko K. Takada; Yoshikazu Takada

doi:10.1074/jbc.M112.412536

Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

Masaaki Fujita, Yoko K. Takada, Yoshikazu Takada

Dermatology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.

Original language	English (US)
Pages (from-to)	3059-3069
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	5
DOIs	https://doi.org/10.1074/jbc.M112.412536
State	Published - Feb 1 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

Access to Document

10.1074/jbc.M112.412536

Fingerprint Dive into the research topics of 'Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation'. Together they form a unique fingerprint.

Cite this

Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation. / Fujita, Masaaki; Takada, Yoko K.; Takada, Yoshikazu.

In: Journal of Biological Chemistry, Vol. 288, No. 5, 01.02.2013, p. 3059-3069.

Research output: Contribution to journal › Article › peer-review

@article{38cd93c78708491793c80dc9a920df4a,

title = "Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation",

abstract = "Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.",

author = "Masaaki Fujita and Takada, {Yoko K.} and Yoshikazu Takada",

year = "2013",

month = feb,

day = "1",

doi = "10.1074/jbc.M112.412536",

language = "English (US)",

volume = "288",

pages = "3059--3069",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "5",

}

TY - JOUR

T1 - Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

AU - Fujita, Masaaki

AU - Takada, Yoko K.

AU - Takada, Yoshikazu

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.

AB - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.

UR - http://www.scopus.com/inward/record.url?scp=84873282225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873282225&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.412536

DO - 10.1074/jbc.M112.412536

M3 - Article

C2 - 23243309

AN - SCOPUS:84873282225

VL - 288

SP - 3059

EP - 3069

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 5

ER -

Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this