Abstract
We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-18 |
| Number of pages | 12 |
| Journal | Biology of the Neonate |
| Volume | 60 |
| Issue number | 1 |
| State | Published - 1991 |
Keywords
- growth factors
- neonate
- puberty
- weaning
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health