Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development

J. S. Singh, L. B. Rall, Dennis M Styne

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

Original languageEnglish (US)
Pages (from-to)7-18
Number of pages12
JournalBiology of the Neonate
Volume60
Issue number1
StatePublished - 1991

Keywords

  • growth factors
  • neonate
  • puberty
  • weaning

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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