Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development

J. S. Singh; L. B. Rall; Dennis M Styne

Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development

J. S. Singh, L. B. Rall, Dennis M Styne

Pediatric Endocrinology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

Original language	English (US)
Pages (from-to)	7-18
Number of pages	12
Journal	Biology of the Neonate
Volume	60
Issue number	1
State	Published - 1991

Keywords

growth factors
neonate
puberty
weaning

ASJC Scopus subject areas

Developmental Biology
Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development'. Together they form a unique fingerprint.

Cite this

@article{de7457d5987c4b9181edb57b3760a751,

title = "Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development",

abstract = "We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.",

keywords = "growth factors, neonate, puberty, weaning",

author = "Singh, {J. S.} and Rall, {L. B.} and Styne, {Dennis M}",

year = "1991",

language = "English (US)",

volume = "60",

pages = "7--18",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development

AU - Singh, J. S.

AU - Rall, L. B.

AU - Styne, Dennis M

PY - 1991

Y1 - 1991

N2 - We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

AB - We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1-7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7-4.0 kb were found, with the 4.0 kb being the most prominent. The pattern of Sernm IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

KW - growth factors

KW - neonate

KW - puberty

KW - weaning

UR - http://www.scopus.com/inward/record.url?scp=0025734080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025734080&partnerID=8YFLogxK

M3 - Article

C2 - 1912101

AN - SCOPUS:0025734080

VL - 60

SP - 7

EP - 18

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 1

ER -

Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this